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M6P/IGF2R Imprinting evolution in mammals


Killian, JK and Byrd, JC and Jirtle, JV and Munday, BL and Stoskopf, MK and McDonald, RG and Jirtle, RL, M6P/IGF2R Imprinting evolution in mammals, Molecular Cell, 5, (4) pp. 707-716. ISSN 1097-2765 (2000) [Refereed Article]

DOI: doi:10.1016/S1097-2765(00)80249-X


Imprinted gene identification in animals has been limited to eutherian mammals, suggesting a significant role for intrauterine fetal development in the evolution of imprinting. We report herein that M6P/IGF2R is not imprinted in monotremes and does not encode for a receptor that binds IGF2. In contrast, M6P/IGF2R is imprinted in a didelphid marsupial, the opossum, but it strikingly lacks the differentially methylated CpG island in intron 2 postulated to be involved in imprint control. Thus, invasive placentation and gestational fetal growth are not required for imprinted genes to evolve. Unless there was convergent evolution of M6P/IGF2R imprinting and receptor IGF2 binding in marsupials and eutherians, our results also demonstrate that these two functions evolved in a mammalian clade exclusive of monotremes.

Item Details

Item Type:Refereed Article
Research Division:Biological Sciences
Research Group:Genetics
Research Field:Molecular evolution
Objective Division:Environmental Management
Objective Group:Other environmental management
Objective Field:Other environmental management not elsewhere classified
UTAS Author:Munday, BL (Dr Barry Munday)
ID Code:19005
Year Published:2000
Web of Science® Times Cited:209
Deposited By:Health Sciences A
Deposited On:2000-08-01
Last Modified:2011-11-21

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