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Melanin density and melanin type predict melanocytic naevi in 19-20 year olds of northern European ancestry


Dwyer, T and Prota, G and Blizzard, CL and Ashbolt, R and Vincensi, M, Melanin density and melanin type predict melanocytic naevi in 19-20 year olds of northern European ancestry, Melanoma Research, 10, (4) pp. 387-394. ISSN 0960-8931 (2000) [Refereed Article]

DOI: doi:10.1097/00008390-200008000-00011


Recent advances in estimating the density of cutaneous melanin by spectrophotometry and the concentration of the two types of melanin (eumelanin and phaeomelanin) in hair offer the potential to define the risk of skin cancer in individuals more accurately. The presence of common melanocytic naevi on the arm is associated with an increased risk of melanoma, and in this study the associations of arm naevi with melanin density at the upper inner arm and with melanin type in hair samples were examined in a representative sample (n = 267) of 19-20 year olds of northern European ancestry. Particularly in men, the association with naevus count was stronger for cutaneous melanin density than for follicular melanin type. Adjusted for recreational sun exposure, the rank correlation coefficients were r = -0.25, 0.12 and 0.01 for men, and r = -0.17, -0.12 and 0.14 for women, for cutaneous melanin, hair eumelanin and hair phaeomelanin, respectively. The associations with less objective markers of phenotype (hair colour, eye colour, nurse-assessed skin colour, and self-reported skin reaction to unaccustomed sun) were weaker. These findings provide important new information that human susceptibility to mutations of melanocytes can be estimated by objective biological measures. The next step is to determine whether these measures also predict the risk of melanoma. (C) 2000 Lippincott Williams and Wilkins.

Item Details

Item Type:Refereed Article
Research Division:Health Sciences
Research Group:Epidemiology
Research Field:Epidemiology not elsewhere classified
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Dwyer, T (Professor Terry Dwyer)
UTAS Author:Blizzard, CL (Professor Leigh Blizzard)
UTAS Author:Ashbolt, R (Mrs Ashbolt)
ID Code:18813
Year Published:2000
Web of Science® Times Cited:14
Deposited By:Menzies Centre
Deposited On:2000-08-01
Last Modified:2007-05-17

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