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Asthma, Inhaled Corticosteroid Use, and Bone Mass in Prepubertal Children
journal contribution
posted on 2023-05-16, 12:05 authored by Graeme JonesGraeme Jones, Ponsonby, AL, Smith, BJ, Carmichael, AThe aim of this Cross-sectional study was to describe the role of asthma, asthma severity, and medication usage in bone mineralization of prepubertal children. Asthma severity, medication usage, and physical activity were assessed by questionnaire and objective measures in 330 children. Bone densitometry and body composition were measured by dual-energy x-ray absorptiometry. Asthma ever was reported by 110 subjects (33%). A diagnosis of asthma was not associated with any deficit in bone mass, whereas usage of inhaled corticosteroids (ICS) in the last year (but not past use) was associated with deficits in bone in the total body (only after adjustment for confounders), particularly for doses of ≥400 μg/day. These observations support current recommendations with regard to ICS usage in children, but require confirmation in longitudinal studies.
History
Publication title
Journal of AsthmaVolume
37Issue
7Pagination
603-611ISSN
0277-0903Department/School
Menzies Institute for Medical ResearchPublisher
Marcel Dekker IncPlace of publication
USARepository Status
- Restricted