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Asthma, Inhaled Corticosteroid Use, and Bone Mass in Prepubertal Children

Citation

Jones, G and Ponsonby, AL and Smith, BJ and Carmichael, A, Asthma, Inhaled Corticosteroid Use, and Bone Mass in Prepubertal Children, Journal of Asthma, 37, (7) pp. 603-611. ISSN 0277-0903 (2000) [Refereed Article]

DOI: doi:10.3109/02770900009090816

Abstract

The aim of this Cross-sectional study was to describe the role of asthma, asthma severity, and medication usage in bone mineralization of prepubertal children. Asthma severity, medication usage, and physical activity were assessed by questionnaire and objective measures in 330 children. Bone densitometry and body composition were measured by dual-energy x-ray absorptiometry. Asthma ever was reported by 110 subjects (33%). A diagnosis of asthma was not associated with any deficit in bone mass, whereas usage of inhaled corticosteroids (ICS) in the last year (but not past use) was associated with deficits in bone in the total body (only after adjustment for confounders), particularly for doses of ≥400 μg/day. These observations support current recommendations with regard to ICS usage in children, but require confirmation in longitudinal studies.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Public Health and Health Services
Research Field:Epidemiology
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Skeletal System and Disorders (incl. Arthritis)
Author:Jones, G (Professor Graeme Jones)
Author:Ponsonby, AL (Professor Anne Ponsonby)
Author:Carmichael, A (Professor Allan Carmichael)
ID Code:18811
Year Published:2000
Web of Science® Times Cited:13
Deposited By:Menzies Centre
Deposited On:2000-08-01
Last Modified:2001-05-04
Downloads:0

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