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Does hemopoietic stem cell transplantation have a role in treatment of severe rheumatoid arthritis?


Lowenthal, RM and Graham, S, Does hemopoietic stem cell transplantation have a role in treatment of severe rheumatoid arthritis?, Journal of Clinical Immunology, 20, (1) pp. 17-23. ISSN 0271-9142 (2000) [Refereed Article]

DOI: doi:10.1023/A:1006634309251


Based on animal models and limited clinical experience, there is considerable interest in use of high-dose immunosuppression followed by hemopoietic stem cell transplantation as treatment for severe rheumatoid arthritis. Because of its relatively low treatment-related mortality and morbidity, autologous transplantation is a more attractive option than allogeneic transplantation for initial clinical trials, even though anecdotal reports suggest that allogeneic transplantation has a greater likelihood of bringing about long-term disease control. The approach remains experimental with many unanswered questions such as the value and safety of high-dose therapy without transplantation, the need for T cell purging, the possible deleterious effects of post-transplant hemopoietic growth factors and the potential of 'mini' allogeneic transplantation (a process whereby intense immunosuppression is combined with less intense myelosuppression). To achieve quick progress it is essential that clinical trials be carefully designed with all cases being reported to the Autoimmune Disease Stem Cell Project Database.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Clinical sciences
Research Field:Rheumatology and arthritis
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Lowenthal, RM (Professor Ray Lowenthal)
UTAS Author:Graham, S (Dr Stewart Graham)
ID Code:18655
Year Published:2000
Web of Science® Times Cited:6
Deposited By:Medicine
Deposited On:2000-08-01
Last Modified:2001-05-03

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