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Nonshivering Thermogenesis in a Marsupial (the Tasmanian Bettong Bettongia gaimardi) Is Not Attributable to Brown Adipose Tissue

Citation

Rose, RW and West, AK and Ye, JM and McCormack, GH and Colquhoun, EQ, Nonshivering Thermogenesis in a Marsupial (the Tasmanian Bettong Bettongia gaimardi) Is Not Attributable to Brown Adipose Tissue, Physiological and Biochemical Zoology, 72, (6) pp. 699-704. ISSN 1522-2152 (1999) [Refereed Article]

DOI: doi:10.1086/316709

Abstract

The Tasmanian bettong (Bettongia gaimardi, a marsupial) is a rat-kangaroo that increases nonshivering thermogenesis (NST) in response to norepinephrine (NE). This study attempted to assess whether brown adipose tissue (BAT), a specialized thermogenic effector, is involved in NST in the bettong. Regulatory NST, indicated by resting oxygen consumption (Vo2) of the whole body, was measured under conscious conditions at 20°C with various stimuli: cold (4°-5°C) or warm (25°C) acclimation, NE injection, and the β-adrenoceptor agonist (BRL) 37344. In line with the functional studies in vivo, the presence of BAT was evaluated by examining the expression of the uncoupling protein 1 (UCP1) with both rat cDNA and oligonucleotide probes. Both NE and BRL 37344 significantly stimulated NST in the bettong. After cold acclimation of the animals (at 4°-5°C for 2 wk), the resting Vo2 was increased by 15% and the thermogenic effect of NE was enhanced; warm-acclimated animals showed a slightly depressed response. However, no expression of UCP1 was detected in bettongs either before or after cold exposure (2 wk). These data suggest that the observed NST in the marsupial bettong is not attributable to BAT.

Item Details

Item Type:Refereed Article
Research Division:Biological Sciences
Research Group:Physiology
Research Field:Comparative Physiology
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in the Environmental Sciences
Author:Rose, RW (Associate Professor Randy Rose)
Author:West, AK (Professor Adrian West)
Author:Ye, JM (Associate Professor Jiming Ye)
Author:McCormack, GH (Mr Graeme McCormack)
Author:Colquhoun, EQ (Dr Eric Colquhoun)
ID Code:17952
Year Published:1999
Web of Science® Times Cited:48
Deposited By:Zoology
Deposited On:1999-08-01
Last Modified:2000-06-07
Downloads:0

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