eCite Digital Repository

Within pair association between birth weight and blood pressure at age 8 in twins from a cohort study

Citation

Dwyer, T and Blizzard, CL and Morley, R and Ponsonby, AL, Within pair association between birth weight and blood pressure at age 8 in twins from a cohort study, British Medical Journal, 319, (7221) pp. 1325-1329. ISSN 0959-8138 (1999) [Refereed Article]

DOI: doi:10.1136/bmj.319.7221.1325

Abstract

Objectives. To study the association between birth weight and blood pressure in children from multiple pregnancies (multiplets), mostly twins, to determine whether maternal or genetic factors are responsible for the association. Design. Cohort study: Setting. Southern Tasmania. Subjects. 888 children including 104 multiplets (32 monozygotic, 72 dizygotic). Main outcome measure. Systolic blood pressure (mm Hg). Results. Blood pressure decreased with birth weight and increased with current body mass. After adjustment for age and body mass, systolic blood pressure changed by -1.94 mm Hg (95% confidence interval -2.89 to -0.98) per 1 kg increase in birth weight of singletons. For multiplets, blood pressure changed by -7.0 mm Hg (-10.1 to -3.9) for each 1 kg increase in birth weight. This was little altered in within pair analyses (-5.3, -13.8 to 3.2) and was similar for both monozygotic (-6.5, -22.5 to 9.4) and dizvgotic (-4.9, -15.8 to 6.0) pairs. Conclusion. Because the association between birth weight and blood pressure was largely unchanged in within pair analyses, exposures originating in the mother (such as nutritional status) cannot be wholly responsible. The association also remained within monozygotic pairs, suggesting that genetic predisposition is not wholly responsible either. The principal causal pathway must concern mechanisms within the fetoplacental unit. The stronger association in multiplets suggests that factors adversely influencing both blood pressure and birth weight are more prevalent in multiple pregnancies.

Item Details

Item Type:Refereed Article
Research Division:Health Sciences
Research Group:Epidemiology
Research Field:Epidemiology not elsewhere classified
Objective Division:Health
Objective Group:Specific population health (excl. Indigenous health)
Objective Field:Neonatal and child health
UTAS Author:Dwyer, T (Professor Terry Dwyer)
UTAS Author:Blizzard, CL (Professor Leigh Blizzard)
UTAS Author:Ponsonby, AL (Professor Anne Ponsonby)
ID Code:17730
Year Published:1999
Web of Science® Times Cited:84
Deposited By:Menzies Centre
Deposited On:1999-08-01
Last Modified:2011-09-27
Downloads:0

Repository Staff Only: item control page