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Dexamethasone suppression test reversal in rapid transcranial magnetic stimulation-treated depression
Objective: The aim of this paper is to report the effect of rapid transcranial magnetic stimulation (rTMS) on the mood and dexamethasone suppression test (DST) of a patient with major depressive disorder (DSM-IV). Clinical picture: A 36-year-old woman with a past history of prolactinoma and recurrent major depressive disorder presented with major depression on three separate occasions over a 3-month period. DST was positive on each occasion. Treatment: During each episode, a course of rTMS was given. Courses varied from seven to 13 once-daily treatment sessions depending on clinical response. These treatment sessions were 20 trains of 10 Hz for 5 s at 100% of motor threshold. Outcome: Remission was achieved, psychiatric rating scales improved and the DST status converted from positive to negative. There were no side effects. Conclusion: DST status in major depressive disorder can be converted from positive to negative by rTMS. This so far unreported observation increases our knowledge of rTMS.
History
Publication title
Australian and New Zealand Journal of PsychiatryVolume
33Pagination
274-277ISSN
0004-8674Department/School
Tasmanian School of MedicinePublisher
Blackwell Science AsiaPlace of publication
Carlton South, VICRepository Status
- Restricted