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Metallothionein in olfactory mucosa of Alzheimer's disease patients and apoE-deficient mice
Citation
Chuah, MI and Getchell, ML, Metallothionein in olfactory mucosa of Alzheimer's disease patients and apoE-deficient mice, NeuroReport, 10, (9) pp. 1919-1924. ISSN 0959-4965 (1999) [Refereed Article]
DOI: doi:10.1097/00001756-199906230-00023
Abstract
Immunostaining for metallothionein was performed on olfactory mucosa of the superior part of the nasal septum obtained from Alzheimer's disease (AD) patients and normal age-matched controls. In general, specimens from AD patients showed increased MT immunoreactivity as indicated by more frequent and intense staining in Bowman's glands, olfactory epithelium and the underlying lamina propria. Induction of MT may result from increased levels of reactive oxygen species commonly associated with AD. Sections of the entire nasal cavity and olfactory bulb of apoE-deficient and wildtype mice revealed no difference in the pattern of staining, suggesting that MT expression is not linked to the apoE gene.
Item Details
Item Type: | Refereed Article |
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Research Division: | Biomedical and Clinical Sciences |
Research Group: | Neurosciences |
Research Field: | Sensory systems |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Clinical health not elsewhere classified |
UTAS Author: | Chuah, MI (Associate Professor Inn Chuah) |
ID Code: | 17419 |
Year Published: | 1999 |
Web of Science® Times Cited: | 13 |
Deposited By: | Anatomy and Physiology |
Deposited On: | 1999-08-01 |
Last Modified: | 2000-05-25 |
Downloads: | 0 |
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