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Endurance training reduces the rate of diaphragm fatigue in vitro
Citation
Vrabas, IS and Dodd, SL and Powers, SK and Hughes, M and Coombes, JS and Fletcher, L and Demirel, HA and Reid, MB, Endurance training reduces the rate of diaphragm fatigue in vitro, Medicine & Science in Sports & Exercise, 31, (11) pp. 1605 - 1612. ISSN 0195-9131 (1999) [Refereed Article]
DOI: doi:10.1097/00005768-199911000-00017
Abstract
Purpose: The present study examined the effects of endurance training on the contractile and biochemical properties of the rat costal diaphragm in vitro. Methods: Sixty-four rats were divided into two groups: exercise trained (T) and control (C). Training consisted of treadmill running 5 d·wk -1 , 60 min·d -1 at ~70% of V̇O(2max), over a 10-wk period. Results: Control diaphragm strips produced an average of 12% less force from minute 15 to 50 of a 60-min in vitro fatigue protocol, compared with the T diaphragm strips (P < 0.01). T diaphragms had 10.1% higher citrate synthase (CS) and 12.1% higher superoxide dismutase (SOD) activities compared with the C (P < 0.05). Despite a significant decrease (P < 0.05) in Type IIb myosin heavy chains (MHC) and an increase (P < 0.05) in Type I MHC in T diaphragms, maximal shortening velocity (V(max)) in the diaphragm was not different between T and C animals. No differences were observed in specific force or the relative proportions of myosin light chains between groups. Conclusions: These findings suggest that endurance training reduces the rate of diaphragm fatigue in vitro but has no effect on V(max) or specific force.
Item Details
Item Type: | Refereed Article |
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Research Division: | Health Sciences |
Research Group: | Sports science and exercise |
Research Field: | Exercise physiology |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Clinical health not elsewhere classified |
UTAS Author: | Coombes, JS (Dr Jeff Coombes) |
ID Code: | 17378 |
Year Published: | 1999 |
Web of Science® Times Cited: | 22 |
Deposited By: | Secondary and Post-Compulsory Education |
Deposited On: | 1999-08-01 |
Last Modified: | 2000-05-05 |
Downloads: | 0 |
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