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The effect of G-CSF on the composition of human bone marrow


Tegg, EM and Tuck, DM and Lowenthal, RM and Marsden, KA, The effect of G-CSF on the composition of human bone marrow, Clinical Laboratory Haematology, 21 pp. 265-270. ISSN 0141-9854 (1999) [Refereed Article]

DOI: doi:10.1046/j.1365-2257.1999.00227.x


The effects on bone marrow cellularity and morphology of 6 days' treatment with granulocyte colony-stimulating factor (G-CSF) in 35 patients were studied. Examination of trephine biopsies showed a highly significant increase in cellularity (P < 10-13). Assessment of aspirates revealed an increase in the myeloid to erythroid (M:E) ratio (P = 0.00006), the proportion of myeloid cells (P< 10-8), myelocytes (P=0.00007), metamyelocytes (P = 0.04), band forms (P = 0.0005) and neutrophils (P = 0.02). This study presents a comprehensive analysis of the effects of six days' administration of G-CSF on human bone marrow.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Oncology and carcinogenesis
Research Field:Oncology and carcinogenesis not elsewhere classified
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Tegg, EM (Dr Elizabeth Tegg)
UTAS Author:Tuck, DM (Mrs Deirdre Tuck)
UTAS Author:Lowenthal, RM (Professor Ray Lowenthal)
UTAS Author:Marsden, KA (Dr Katherine Marsden)
ID Code:15917
Year Published:1999
Web of Science® Times Cited:9
Deposited By:Medicine
Deposited On:1999-08-01
Last Modified:2000-05-26

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