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The effect of G-CSF on the composition of human bone marrow
journal contribution
posted on 2023-05-16, 11:34 authored by Tegg, EM, Deirdre TuckDeirdre Tuck, Raymond Lowenthal, Marsden, KAThe effects on bone marrow cellularity and morphology of 6 days' treatment with granulocyte colony-stimulating factor (G-CSF) in 35 patients were studied. Examination of trephine biopsies showed a highly significant increase in cellularity (P < 10-13). Assessment of aspirates revealed an increase in the myeloid to erythroid (M:E) ratio (P = 0.00006), the proportion of myeloid cells (P< 10-8), myelocytes (P=0.00007), metamyelocytes (P = 0.04), band forms (P = 0.0005) and neutrophils (P = 0.02). This study presents a comprehensive analysis of the effects of six days' administration of G-CSF on human bone marrow.
History
Publication title
Clinical Laboratory HaematologyVolume
21Pagination
265-270ISSN
0141-9854Department/School
Tasmanian School of MedicinePublisher
Blackwell SciencesPlace of publication
Oxford, UKRepository Status
- Restricted