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Correlation between functional and electrophysiological recovery in acute ischemic stroke


Vang, C and Dunbabin, DW and Kilpatrick, D, Correlation between functional and electrophysiological recovery in acute ischemic stroke, Stroke, 30, (10) pp. 2126-2130. ISSN 0039-2499 (1999) [Refereed Article]

DOI: doi:10.1161/01.STR.30.10.2126


Background and Purpose - There is still controversy about the prognostic value of motor evoked potentials (MEPs) in the assessment of hemiplegia. The aims of this study are to determine the relationship between functional and electrophysiological recovery and thus the value of MEP as a prognostic indicator of clinical outcome in acute ischemic stroke. Methods - Seventeen healthy subjects and 38 stroke patients were included in this study. Functional recovery was assessed with the Modified Canadian Neurological Scale (MCNS), the Barthel Activities of Daily Living Index (BI), and the Rankin scale. Transcranial magnetic stimulation was used to determine the change in central motor conduction time (CMCT). Stroke outcome was assessed at the end of 2 weeks. One-way ANOVA with post hoc comparisons using the Scheffe procedure as well as t tests were used to assess the significance of the results in this study. Results - Unpaired t test showed significantly higher mean scores of the MCNS (2P=0.001), BI (2P=0.002), and Rankin scale (P<0.001) at day 14 in the group of patients with recordable MEP at day 1. A better clinical improvement with a higher mean score of the MCNS (2P<0.001), BI (2P<0.001), and the Rankin scale (2P<0.001) was also observed in the patients in whom the CMCT improved. Conclusions - These data show that there is a close relationship between clinical and electrophysiological improvement and that MEP is a useful prognostic indicator of clinical outcome.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Neurology and neuromuscular diseases
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Vang, C (Dr Chu Vang)
UTAS Author:Dunbabin, DW (Dr David Dunbabin)
UTAS Author:Kilpatrick, D (Professor David Kilpatrick)
ID Code:15911
Year Published:1999
Web of Science® Times Cited:30
Deposited By:Medicine
Deposited On:1999-08-01
Last Modified:2011-11-28

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