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Epicardial ST depression in acute myocardial infarction


Li, DS and Li, CY and Yong, AC and Johnston, PR and Kilpatrick, D, Epicardial ST depression in acute myocardial infarction, Circulation Research, 85, (10) pp. 959-964. ISSN 0009-7330 (1999) [Refereed Article]

DOI: doi:10.1161/01.RES.85.10.959


The presence of electrocardiographic ST depression in acute infarction remains controversial and poorly explained. A combined animal and modeling study was performed to evaluate the source of ST changes in acute infarction. In anaesthetized sheep, small infarcts showed uniform ST elevation over the infarction whereas larger infarcts showed marked ST depression over the normal myocardium in addition to the ST elevation. These findings were replicated by bidomain models of the heart. A hollow sphere was used to model a gradually increasing infarct, and this showed that there was a decrease in the ratio of ST elevation to ST depression as the infarct was increased. The current flowing out of the heart must be identical to the current flowing back into the heart. This means that any infarction will produce ST depression as well as ST elevation, the ratio between the two being related to the size of the infarction. Small infarction is associated with a small region of ST elevation and minor ST depression of the remaining myocardium, and as the infarct region increases, the amplitude of the epicardial ST elevation falls and the amplitude of the ST depression increases. Infarction size is proportional to both the height of the ST depression on the epicardium and the strength of the epicardial ST segment dipole.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Cardiovascular medicine and haematology
Research Field:Cardiology (incl. cardiovascular diseases)
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Li, DS (Ms Danshi Li)
UTAS Author:Li, CY (Ms Chuan Yong Li)
UTAS Author:Yong, AC (Dr Ah Chot Yong)
UTAS Author:Johnston, PR (Dr Peter Johnston)
UTAS Author:Kilpatrick, D (Professor David Kilpatrick)
ID Code:15905
Year Published:1999
Web of Science® Times Cited:14
Deposited By:Medicine
Deposited On:1999-08-01
Last Modified:2011-09-29

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