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At least three genes account for familial papillary thyroid carcinoma: TCO and MNG1 excluded as susceptibility loci from a large Tasmanian family

Citation

McKay, JD and Williamson, J and Lesueur, F and Stark, M and Duffield, A and Canzian, F and Romeo, G and Hoffman, L, At least three genes account for familial papillary thyroid carcinoma: TCO and MNG1 excluded as susceptibility loci from a large Tasmanian family, European Journal of Endocrinology, 141 pp. 122-125. ISSN 0804-4643 (1999) [Refereed Article]

DOI: doi:10.1530/eje.0.1410122

Abstract

Recent studies have mapped two susceptibility loci which appear to account for familial multinodular goitre (MNG1) and a variant of familial papillary thyroid cancer (PTC), with associated multinodular goitre (TCO). A Tasmanian family (Tas1) has been identified with an autosomal dominant form of PTC. This study has examined the MNG1 and TCO loci to determine if they are similarly predisposing the Tas1 family to PTC. Linkage analysis using identical microsatellite markers described in the two previous studies was used to determine the significance of these loci in the Tasmanian family. The resultant LOD scores were sufficiently negative using multipoint parametric analysis to exclude these two loci from involvement in the Tasmanian family. In addition, six candidate genes, RET, TRK, MET, TSHR, APC and PTEN were also excluded as susceptibility genes in Tas1 by using microsatellites that are positioned in or in close proximity to these genes. These results suggest that there are at least three susceptibility genes that predispose families to familial PTC.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Clinical Sciences
Research Field:Endocrinology
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Diabetes
Author:McKay, JD (Dr James McKay)
Author:Duffield, A (Dr Anne Duffield)
Author:Hoffman, L (Associate Professor Linda Hoffman)
ID Code:15903
Year Published:1999
Web of Science® Times Cited:24
Deposited By:Medicine (Discipline)
Deposited On:1999-08-01
Last Modified:2000-06-02
Downloads:0

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