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Pharmacokinetics of intravenously administered ketamine in southern elephant seals (Mirounga leonina)


Woods, R and McLean, SR and Burton, H, Pharmacokinetics of intravenously administered ketamine in southern elephant seals (Mirounga leonina), Comparative Biochemistry and Physiology, 123, (3) pp. 279-284. ISSN 0010-406X (1999) [Refereed Article]

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DOI: doi:10.1016/S0742-8413(99)00035-3


Southern elephant seals (Mirounga leonina) are large, potentially dangerous animals which must be restrained before study or treatment. However, chemical restraint is unpredictable, possibly because of differences in body composition during fasting ashore, and circulatory adaptations to enable diving. The pharmacokinetics of ketamine (1.1 mg/kg i.v.) was studied in 15 southern elephant seals which had come ashore on Macquarie Island. The animals were first sedated with pethidine (5 mg/kg i.m.) to allow intravenous access. There was great variability in the calculated pharmacokinetic parameters, possibly due to circulatory changes associated with periods of apnoea which characterise this animal's response to anaesthetics. The median values were similar to those reported for other species: distribution t1/2 = 2.5 min (range 1-11 min); elimination t1/2 = 43 min (range 17-108 min); apparent volume of distribution, 1474 ml/kg (range 830-9301 ml/kg); clearance, 33 ml/min/kg (range 12-57 ml/min/kg). This was the first investigation of drug disposition in any seal species. and the first in any free-ranging wild animal. It is important to obtain pharmacological data in animals in whom drugs are used, but pre-catheterised captive animals may provide less variable data.

Item Details

Item Type:Refereed Article
Keywords:elephant seal; elephant; southern elephant; ketamine; seal; leonina; seal mirounga; mirounga; pharmacokinetic; administer ketamine; southern; animal; ml/min/kg; intravenously administer; dive;
Research Division:Agricultural, Veterinary and Food Sciences
Research Group:Veterinary sciences
Research Field:Veterinary pharmacology
Objective Division:Environmental Management
Objective Group:Terrestrial systems and management
Objective Field:Terrestrial biodiversity
UTAS Author:Woods, R (Dr Rupert Woods)
UTAS Author:McLean, SR (Professor Stuart McLean)
ID Code:15886
Year Published:1999
Web of Science® Times Cited:5
Deposited By:Pharmacy
Deposited On:1999-08-01
Last Modified:2011-07-21
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