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p53 protects against skin cancer induction by UV-B irradiation


Jiang, W and Ananthaswamy, HN and Muller, HK and Kripke, ML, p53 protects against skin cancer induction by UV-B irradiation, Oncogene, 18, (29) pp. 4247-4253. ISSN 0950-9232 (1999) [Refereed Article]

DOI: doi:10.1038/sj.onc.1202789


To assess the role of the p53 tumor suppressor gene in skin carcinogenesis by UV radiation, mice constitutively lacking one or both copies of the functional p53 gene mere compared to mild-type mice for their susceptibility to UV carcinogenesis. Heterozygous mice showed greatly increased susceptibility to skill cancer induction, and homozygous p53 knockout mice were even more susceptible. Accelerated tumor development in the heterozygotes was not associated with loss of the remaining wild-type allele of p53, as reported for tumors induced by other carcinogens, but in many cases was associated with UV-induced mutations in p53. Tumors arose on the ears and dorsal skin of mice of all three genotypes, and homozygous knockout mice also developed ocular tumors, mainly melanomas. Skin tumors in the p53 knockout mice were predominately squamous cell carcinomas and were associated with premalignant lesions resembling actinic keratoses, whereas those in the heterozygous and wild-type mice were mainly sarcomas. These results demonstrate the importance of p53 in protecting against UV-induced cancers, particularly in the eye and epidermis.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Oncology and carcinogenesis
Research Field:Oncology and carcinogenesis not elsewhere classified
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Muller, HK (Professor Konrad Muller)
ID Code:15819
Year Published:1999
Web of Science® Times Cited:139
Deposited By:Pathology
Deposited On:1999-08-01
Last Modified:2000-05-26

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