eCite Digital Repository

The impact of comorbidities on health-related quality of life of people with osteoarthritis over 10 years


Zhao, T and Winzenberg, T and Aitken, D and de Graaff, B and Ahmad, H and Jones, Graeme and Palmer, AJ, The impact of comorbidities on health-related quality of life of people with osteoarthritis over 10 years, Rheumatology, 61, (1) pp. 139-145. ISSN 1462-0332 (2021) [Refereed Article]

Pending copyright assessment - Request a copy

DOI: doi:10.1093/rheumatology/keab358


Objective: To investigate the impact of total number and patterns of comorbidities on health-related quality of life (HRQoL) and identify the most prevalent and influential comorbidity patterns in people with OA over 10 years.

Methods: Participants from the Tasmanian Older Adult Cohort aged 50-80 years, with self-reported OA and data on comorbidities and HRQoL were included. Participants were interviewed at baseline (n = 398), 2.5 (n = 304), 5 (n = 269) and 10 years (n = 191). Data on the self-reported presence of 10 chronic comorbidities were collected at baseline. HRQoL was assessed using the Assessment of Quality of Life-4-Dimensions. The long-term impacts of the number and of the nine most prevalent combinations of cardiovascular (CVD), non-OA musculoskeletal (Ms), metabolic and respiratory comorbidities on HRQoL over 10 years were analysed using linear mixed regressions.

Results: Compared with comorbidity-free OA participants, the health state utility (HSU) of those with 2 or ≥3 comorbidities was respectively -0.07 and -0.13 units lower over 10 years, largely driven by reduced scores for independent living, social relationships and psychological wellness. Comorbidity patterns including 'CVD+Ms' were most influential, and associated with up to 0.13 units lower HSU, mostly through negative impacts on independent living (up to -0.12), psychological wellness (up to -0.08) and social relationship (up to -0.06).

Conclusion: Having more comorbidities negatively impacted OA patients' long-term HRQoL. OA patients with CVD and non-OA musculoskeletal conditions had the largest HSU impairment, and therefore optimal management and prevention of these conditions may yield improvements in OA patients' HRQoL.

Item Details

Item Type:Refereed Article
Keywords:HRQoL; HSUs; comorbidity count; comorbidity patterns; osteoarthritis; the AQoL-4D.
Research Division:Biomedical and Clinical Sciences
Research Group:Clinical sciences
Research Field:Rheumatology and arthritis
Objective Division:Health
Objective Group:Clinical health
Objective Field:Treatment of human diseases and conditions
UTAS Author:Zhao, T (Dr Ting Zhao)
UTAS Author:Winzenberg, T (Professor Tania Winzenberg)
UTAS Author:Aitken, D (Associate Professor Dawn Aitken)
UTAS Author:de Graaff, B (Dr Barbara de Graaff)
UTAS Author:Ahmad, H (Dr Hasnat Ahmad)
UTAS Author:Jones, Graeme (Professor Graeme Jones)
UTAS Author:Palmer, AJ (Professor Andrew Palmer)
ID Code:155647
Year Published:2021
Deposited By:Menzies Institute for Medical Research
Deposited On:2023-03-03
Last Modified:2023-03-06

Repository Staff Only: item control page