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Cost-effectiveness of polygenic risk profiling for primary open-angle glaucoma in the United Kingdom and Australia

Citation

Liu, Q and Davis, J and Han, X and Mackey, DA and MacGregor, S and Craig, JE and Si, L and Hewitt, AW, Cost-effectiveness of polygenic risk profiling for primary open-angle glaucoma in the United Kingdom and Australia, Eye (London) pp. 1-9. ISSN 1476-5454 (2022) [Refereed Article]


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DOI: doi:10.1038/s41433-022-02346-2

Abstract

Background: Primary open-angle glaucoma (POAG) is the most common subtype of glaucoma. We evaluate the cost-effectiveness of polygenic risk score (PRS) profiling as a screening tool for POAG. Methods: We used a Markov cohort model to evaluate the cost-effectiveness of implementing PRS screening in the UK and Australia, conducted from the healthcare payer’s perspective. We used published data to calculate prevalence, transition probabilities, utility, cost and other parameters in the model. Our main outcome measure was the incremental cost-effectiveness ratio (ICER) and secondary outcomes were years of blindness avoided and a ‘Blindness ICER’. We did one-way as well as two-way deterministic and probabilistic sensitivity analyses. Results: The proposed screening programme for POAG in the UK is predicted to result in ICER of £24,783 (95% CI: £13,373"66,960) and would avoid 1 year of blindness at ICER of £10,095 (95% CI: £5513"27,656). In Australia, it is predicted to result in ICER of AU$34,252 (95% CI: AU$21,324"95,497) and would avoid 1 year of blindness at ICER of AU$13,359 (95% CI: AU$8143"37,448). Using the willingness to pay thresholds of $54,808 and £30,000, the proposed screening model is 79.2% likely to be cost-effective in Australia and is 60.2% likely to be cost-effective in the UK, respectively. Conclusion: We describe and model the cost-efficacy of incorporating a polygenic risk score for POAG screening in Australia and the UK for the first time and results indicated this is a promising cost-effectiveness strategy.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Ophthalmology and optometry
Research Field:Optical technology
Objective Division:Health
Objective Group:Evaluation of health and support services
Objective Field:Health education and promotion
UTAS Author:Mackey, DA (Professor David Mackey)
UTAS Author:Hewitt, AW (Professor Alex Hewitt)
ID Code:155576
Year Published:2022
Deposited By:Menzies Institute for Medical Research
Deposited On:2023-03-01
Last Modified:2023-03-01
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