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Childhood sleep health and epigenetic age acceleration in late adolescence: cross-sectional and longitudinal analyses

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posted on 2023-05-21, 16:40 authored by Balfour, D, Phillip MeltonPhillip Melton, McVeigh, JE, Huang, R-C, Eastwood, PR, Wanstall, S, Reynolds, AC, Cohen-Woods, S

Aim: Investigate if childhood measures of sleep health are associated with epigenetic age acceleration in late adolescence.

Methods: Parent-reported sleep trajectories from age 5 to 17, self-reported sleep problems at age 17, and six measures of epigenetic age acceleration at age 17 were studied in 1,192 young Australians from the Raine Study Gen2.

Results: There was no evidence for a relationship between the parent-reported sleep trajectories and epigenetic age acceleration (p ≥ .17). There was a positive cross-sectional relationship between self-reported sleep problem score and intrinsic epigenetic age acceleration at age 17 (b = 0.14, p = .04), which was attenuated after controlling for depressive symptom score at the same age (b = 0.08, p = .34). Follow-up analyses suggested this finding may represent greater overtiredness and intrinsic epigenetic age acceleration in adolescents with higher depressive symptoms.

Conclusion: There was no evidence for a relationship between self- or parent-reported sleep health and epigenetic age acceleration in late adolescence after adjusting for depressive symptoms. Mental health should be considered as a potential confounding variable in future research on sleep and epigenetic age acceleration, particularly if subjective measures of sleep are used.

History

Publication title

Acta Paediatrica

ISSN

0803-5253

Department/School

Menzies Institute for Medical Research

Publisher

Taylor & Francis As

Place of publication

Cort Adelersgt 17, Po Box 2562, Solli, Oslo, Norway, 0202

Rights statement

© 2023 The Authors. Acta Paediatrica published by John Wiley & Sons Ltd on behalf of Foundation Acta Paediatrica. This is an open access article under the terms of the Creative Commons Attribution 4.0 International (CC BY 4.0) License, https://creativecommons.org/licenses/by/4.0/ which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Repository Status

  • Open

Socio-economic Objectives

Clinical health not elsewhere classified; Behaviour and health

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