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Can maternal exposure to air pollution affect post-natal liver development?


Song, Y and Chen, L and Bennett, E and Wheeler, AJ and Southam, K and Yen, S and Johnston, F and Zosky, GR, Can maternal exposure to air pollution affect post-natal liver development?, Toxics, 11, (1) pp. 1-9. ISSN 2305-6304 (2023) [Refereed Article]

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DOI: doi:10.3390/toxics11010061


Emerging evidence suggests that inhalation of particulate matter (PM) can have direct adverse effects on liver function. Early life is a time of particular vulnerability to the effects of air pollution. On that basis, we tested whether in utero exposure to residential PM has an impact on the developing liver. Pregnant mice (C57BL/6J) were intranasally administered 100 g of PM sampled from residential roof spaces (~5 mg/kg) on gestational days 13.5, 15.5, and 17.5. The pups were euthanized at two weeks of age, and liver tissue was collected to analyse hepatic metabolism (glycogen storage and lipid level), cellular responses (oxidative stress, inflammation, and fibrosis), and genotoxicity using a range of biochemical assays, histological staining, ELISA, and qPCR. We did not observe pronounced effects of environmentally sampled PM on the developing liver when examining hepatic metabolism and cellular response. However, we did find evidence of liver genomic DNA damage in response to in utero exposure to PM. This effect varied depending on the PM sample. These data suggest that in utero exposure to real-world PM during mid-late pregnancy has limited impacts on post-natal liver development.

Item Details

Item Type:Refereed Article
Keywords:air pollution, early life, liver development, particulate matter
Research Division:Biomedical and Clinical Sciences
Research Group:Clinical sciences
Research Field:Gastroenterology and hepatology
Objective Division:Health
Objective Group:Clinical health
Objective Field:Prevention of human diseases and conditions
UTAS Author:Song, Y (Dr Yong Song)
UTAS Author:Bennett, E (Dr Ellen Bennett)
UTAS Author:Wheeler, AJ (Dr Amanda Wheeler)
UTAS Author:Southam, K (Dr Katherine Southam)
UTAS Author:Yen, S (Dr Seiha Yen)
UTAS Author:Johnston, F (Professor Fay Johnston)
UTAS Author:Zosky, GR (Professor Graeme Zosky)
ID Code:155474
Year Published:2023
Deposited By:College Office - CHM
Deposited On:2023-02-21
Last Modified:2023-02-22

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