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The role of altered protein acetylation in neurodegenerative disease


Kabir, F and Atkinson, R and Cook, AL and Phipps, AJ and King, AE, The role of altered protein acetylation in neurodegenerative disease, Frontiers in Aging Neuroscience, 14 pp. 1-24. ISSN 1663-4365 (2023) [Refereed Article]

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DOI: doi:10.3389/fnagi.2022.1025473


Acetylation is a key post-translational modification (PTM) involved in the regulation of both histone and non-histone proteins. It controls cellular processes such as DNA transcription, RNA modifications, proteostasis, aging, autophagy, regulation of cytoskeletal structures, and metabolism. Acetylation is essential to maintain neuronal plasticity and therefore essential for memory and learning. Homeostasis of acetylation is maintained through the activities of histone acetyltransferases (HAT) and histone deacetylase (HDAC) enzymes, with alterations to these tightly regulated processes reported in several neurodegenerative diseases including Alzheimerís disease (AD), Parkinsonís disease (PD), Huntingtonís disease (HD), and amyotrophic lateral sclerosis (ALS). Both hyperacetylation and hypoacetylation can impair neuronal physiological homeostasis and increase the accumulation of pathophysiological proteins such as tau, α-synuclein, and Huntingtin protein implicated in AD, PD, and HD, respectively. Additionally, dysregulation of acetylation is linked to impaired axonal transport, a key pathological mechanism in ALS. This review article will discuss the physiological roles of protein acetylation and examine the current literature that describes altered protein acetylation in neurodegenerative disorders.

Item Details

Item Type:Refereed Article
Keywords:PTMs, acetylation, HDACs, HATs, proteostasis, cytoskeleton neurodegenerative disease.
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Neurology and neuromuscular diseases
Objective Division:Health
Objective Group:Clinical health
Objective Field:Prevention of human diseases and conditions
UTAS Author:Kabir, F (Mrs Fariha Kabir)
UTAS Author:Atkinson, R (Dr Rachel Atkinson)
UTAS Author:Cook, AL (Associate Professor Tony Cook)
UTAS Author:Phipps, AJ (Dr Andrew Phipps)
UTAS Author:King, AE (Professor Anna King)
ID Code:154879
Year Published:2023
Deposited By:Wicking Dementia Research and Education Centre
Deposited On:2023-01-17
Last Modified:2023-01-17

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