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The role of altered protein acetylation in neurodegenerative disease
Citation
Kabir, F and Atkinson, R and Cook, AL and Phipps, AJ and King, AE, The role of altered protein acetylation in neurodegenerative disease, Frontiers in Aging Neuroscience, 14 pp. 1-24. ISSN 1663-4365 (2023) [Refereed Article]
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DOI: doi:10.3389/fnagi.2022.1025473
Abstract
Acetylation is a key post-translational modification (PTM) involved in the regulation of both histone and non-histone proteins. It controls cellular processes such as DNA transcription, RNA modifications, proteostasis, aging, autophagy, regulation of cytoskeletal structures, and metabolism. Acetylation is essential to maintain neuronal plasticity and therefore essential for memory and learning. Homeostasis of acetylation is maintained through the activities of histone acetyltransferases (HAT) and histone deacetylase (HDAC) enzymes, with alterations to these tightly regulated processes reported in several neurodegenerative diseases including Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), and amyotrophic lateral sclerosis (ALS). Both hyperacetylation and hypoacetylation can impair neuronal physiological homeostasis and increase the accumulation of pathophysiological proteins such as tau, α-synuclein, and Huntingtin protein implicated in AD, PD, and HD, respectively. Additionally, dysregulation of acetylation is linked to impaired axonal transport, a key pathological mechanism in ALS. This review article will discuss the physiological roles of protein acetylation and examine the current literature that describes altered protein acetylation in neurodegenerative disorders.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Keywords: | PTMs, acetylation, HDACs, HATs, proteostasis, cytoskeleton neurodegenerative disease. |
| Research Division: | Biomedical and Clinical Sciences |
| Research Group: | Neurosciences |
| Research Field: | Neurology and neuromuscular diseases |
| Objective Division: | Health |
| Objective Group: | Clinical health |
| Objective Field: | Prevention of human diseases and conditions |
| UTAS Author: | Kabir, F (Mrs Fariha Kabir) |
| UTAS Author: | Atkinson, R (Dr Rachel Atkinson) |
| UTAS Author: | Cook, AL (Associate Professor Tony Cook) |
| UTAS Author: | Phipps, AJ (Dr Andrew Phipps) |
| UTAS Author: | King, AE (Professor Anna King) |
| ID Code: | 154879 |
| Year Published: | 2023 |
| Deposited By: | Wicking Dementia Research and Education Centre |
| Deposited On: | 2023-01-17 |
| Last Modified: | 2023-01-17 |
| Downloads: | 0 |
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