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The relative contribution of co-morbidities to health-related quality of life of people with idiopathic pulmonary fibrosis using the Assessment of Quality of Life-8-Dimension multi-attribute utility instrument

journal contribution
posted on 2023-05-21, 15:40 authored by Zheng, Q, Ingrid CoxIngrid Cox, Barbara de GraaffBarbara de Graaff, Julie CampbellJulie Campbell, Corte, TJ, Glaspole, I, Navaratnam, V, Hopkins, P, Zappala, C, Hasnat AhmadHasnat Ahmad, Ting ZhaoTing Zhao, Macansh, S, Eugene WaltersEugene Walters, Andrew PalmerAndrew Palmer

Purpose: Little is known about the impact of co-morbidities on health-related quality of life (HRQoL) for people with idiopathic pulmonary fibrosis (IPF). We aimed to investigate the relative contribution of co-morbidities to HRQoL of people with IPF.

Methods: N = 157 participants were recruited from the Australian IPF Registry (AIPFR). Health state utilities (HSUs), and the super-dimensions of physical and psychosocial scores were measured using the Assessment of Quality of Life-8-Dimensions (AQoL-8D). The impact of co-morbidities on HRQoL was investigated using linear regression and general dominance analyses.

Results: A higher number of co-morbidities was associated with lower HSUs (p trend = 0.002). Co-morbidities explained 9.1% of the variance of HSUs, 16.0% of physical super-dimensional scores, and 4.2% of psychosocial super-dimensional scores. Arthritis was associated with a significant reduction on HSUs (β =  − 0.09, 95% confidence interval [CI] − 0.16 to − 0.02), largely driven by reduced scores on the physical super-dimension (β =  − 0.13, 95% CI − 0.20 to − 0.06). Heart diseases were associated with a significant reduction on HSUs (β =  − 0.09, 95% CI − 0.16 to − 0.02), driven by reduced scores on physical (β =  − 0.09, 95% CI − 0.16 to − 0.02) and psychosocial (β = -0.10, 95% CI − 0.17 to − 0.02) super-dimensions.

Conclusions: Co-morbidities significantly impact HRQoL of people with IPF, with markedly negative impacts on their HSUs and physical health. A more holistic approach to the care of people with IPF is important as better management of these co-morbidities could lead to improved HRQoL in people with IPF.

History

Publication title

Quality of Life Research

Article number

online ahead of print

Number

online ahead of print

ISSN

0962-9343

Department/School

Menzies Institute for Medical Research

Publisher

Kluwer Academic Publ

Place of publication

Van Godewijckstraat 30, Dordrecht, Netherlands, 3311 Gz

Rights statement

© The Author(s), under exclusive licence to Springer Nature Switzerland AG 2022.

Repository Status

  • Restricted

Socio-economic Objectives

Evaluation of health outcomes

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