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The relative contribution of co-morbidities to health-related quality of life of people with idiopathic pulmonary fibrosis using the Assessment of Quality of Life-8-Dimension multi-attribute utility instrument

Citation

Zheng, Q and Cox, IA and de Graaff, B and Campbell, JA and Corte, TJ and Glaspole, I and Navaratnam, V and Hopkins, P and Zappala, C and Ahmad, H and Zhao, T and Macansh, S and Walters, EH and Palmer, AJ, The relative contribution of co-morbidities to health-related quality of life of people with idiopathic pulmonary fibrosis using the Assessment of Quality of Life-8-Dimension multi-attribute utility instrument, Quality of Life Research Article online ahead of print. ISSN 0962-9343 (2022) [Refereed Article]


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DOI: doi:10.1007/s11136-022-03331-8

Abstract

Purpose: Little is known about the impact of co-morbidities on health-related quality of life (HRQoL) for people with idiopathic pulmonary fibrosis (IPF). We aimed to investigate the relative contribution of co-morbidities to HRQoL of people with IPF.

Methods: N = 157 participants were recruited from the Australian IPF Registry (AIPFR). Health state utilities (HSUs), and the super-dimensions of physical and psychosocial scores were measured using the Assessment of Quality of Life-8-Dimensions (AQoL-8D). The impact of co-morbidities on HRQoL was investigated using linear regression and general dominance analyses.

Results: A higher number of co-morbidities was associated with lower HSUs (p trend = 0.002). Co-morbidities explained 9.1% of the variance of HSUs, 16.0% of physical super-dimensional scores, and 4.2% of psychosocial super-dimensional scores. Arthritis was associated with a significant reduction on HSUs (β =  − 0.09, 95% confidence interval [CI] − 0.16 to − 0.02), largely driven by reduced scores on the physical super-dimension (β =  − 0.13, 95% CI − 0.20 to − 0.06). Heart diseases were associated with a significant reduction on HSUs (β =  − 0.09, 95% CI − 0.16 to − 0.02), driven by reduced scores on physical (β =  − 0.09, 95% CI − 0.16 to − 0.02) and psychosocial (β = -0.10, 95% CI − 0.17 to − 0.02) super-dimensions.

Conclusions: Co-morbidities significantly impact HRQoL of people with IPF, with markedly negative impacts on their HSUs and physical health. A more holistic approach to the care of people with IPF is important as better management of these co-morbidities could lead to improved HRQoL in people with IPF.

Item Details

Item Type:Refereed Article
Keywords:idiopathic pulmonary fibrosis, respiratory disease, health related qulaity of life, EQ5D, AQOL
Research Division:Biomedical and Clinical Sciences
Research Group:Cardiovascular medicine and haematology
Research Field:Respiratory diseases
Objective Division:Health
Objective Group:Evaluation of health and support services
Objective Field:Evaluation of health outcomes
UTAS Author:Zheng, Q (Mr Qiang Zheng)
UTAS Author:Cox, IA (Dr Ingrid Cox)
UTAS Author:de Graaff, B (Dr Barbara de Graaff)
UTAS Author:Campbell, JA (Dr Julie Campbell)
UTAS Author:Ahmad, H (Dr Hasnat Ahmad)
UTAS Author:Zhao, T (Dr Ting Zhao)
UTAS Author:Walters, EH (Professor Haydn Walters)
UTAS Author:Palmer, AJ (Professor Andrew Palmer)
ID Code:154837
Year Published:2022
Deposited By:Menzies Institute for Medical Research
Deposited On:2023-01-12
Last Modified:2023-01-18
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