eCite Digital Repository

Markers of Epstein-Barr virus and Human Herpesvirus-6 infection and multiple sclerosis clinical progression


Tao, C and Simpson-Yap, S and Taylor, B and Blizzard, L and Lucas, R and Ponsonby, AL and Broadley, S and van der Mei, I, AusLong/Ausimmune Investigators Group, Markers of Epstein-Barr virus and Human Herpesvirus-6 infection and multiple sclerosis clinical progression, Multiple Sclerosis and Related Disorders, 59 Article 103561. ISSN 2211-0356 (2022) [Refereed Article]

Copyright Statement

2022 Elsevier B.V.

DOI: doi:10.1016/j.msard.2022.103561


Background:have been implicated in multiple sclerosis (MS) onset but little work has studied their relationships in early disease.

Objectives:Evaluate associations between markers of EBV and HHV-6 infection/reactivation and MS conversion, relapse and EDSS/MSSS amongst 205 CIS participants with EBV/HHV-6 data followed over 5 years.

Method:Baseline serological and viral load measures of EBV and HHV-6 exposure/reactivation were measured and infectious mononucleosis (IM) history recorded. Conversion to MS and relapses were assessed annually, and EDSS/MSSS measured at 5-year review. Determinants of MS conversion and relapse assessed by Cox regression, and disability progression by linear regression.

Results:IM history showed a strong positive trend with higher relapse risk (aHR=1.45,95%CI=0.97-2.16) but was not associated with MS conversion (aHR=0.92,95%CI=0.57-1.48). Anti-HHV-6 IgG titre>40 also showed strong positive trends with higher relapse (aHR=1.61,95%CI=0.99-2.63) and MS conversion risks (aHR=1.48,95%CI=0.89-2.46). Anti-HHV-6 IgG titre≥640 was significantly associated with higher MSSS (0.15(95%CI=0.00,0.30) and also showed a strong positive trend with higher EDSS 0.10(95%CI=-0.02,0.21). HHV-6 DNA detection showed strong positive trends with 83%(95%CI=-6-357) and 77%(95%CI=-4-328) higher MS conversion and relapse risk. Anti-EBV-EA-D IgG titre was associated with a lower annualised disability progression by EDSS (ptrend=0.037) and also showed strong positive trend with higher MSSS (ptrend=0.053). No associations were seen for other serological or viral load markers.

Conclusions:Overall, our data provides evidence that higher HHV-6 IgG was associated with increased risk of MS conversion and relapse but of borderline significance, and greater annualised disability progression, while that for EBV was more limited.

Item Details

Item Type:Refereed Article
Keywords:first demyelinating event, conversion, relapse, Epstein-Barr virus, human herpesvirus-6, multiple sclerosis
Research Division:Health Sciences
Research Group:Epidemiology
Research Field:Epidemiology not elsewhere classified
Objective Division:Health
Objective Group:Clinical health
Objective Field:Prevention of human diseases and conditions
UTAS Author:Tao, C (Mr Chunrong Tao)
UTAS Author:Simpson-Yap, S (Dr Steve Simpson JR)
UTAS Author:Taylor, B (Professor Bruce Taylor)
UTAS Author:Blizzard, L (Professor Leigh Blizzard)
UTAS Author:van der Mei, I (Professor Ingrid van der Mei)
ID Code:154298
Year Published:2022
Web of Science® Times Cited:1
Deposited By:Menzies Institute for Medical Research
Deposited On:2022-11-22
Last Modified:2022-12-23

Repository Staff Only: item control page