University of Tasmania
Browse

File(s) under permanent embargo

Markers of Epstein-Barr virus and Human Herpesvirus-6 infection and multiple sclerosis clinical progression

journal contribution
posted on 2023-05-21, 14:57 authored by Tao, C, Steve Simpson JRSteve Simpson JR, Bruce TaylorBruce Taylor, Christopher BlizzardChristopher Blizzard, Lucas, R, Ponsonby, AL, Broadley, S, Ingrid van der MeiIngrid van der Mei

Background:have been implicated in multiple sclerosis (MS) onset but little work has studied their relationships in early disease.

Objectives:Evaluate associations between markers of EBV and HHV-6 infection/reactivation and MS conversion, relapse and EDSS/MSSS amongst 205 CIS participants with EBV/HHV-6 data followed over 5 years.

Method:Baseline serological and viral load measures of EBV and HHV-6 exposure/reactivation were measured and infectious mononucleosis (IM) history recorded. Conversion to MS and relapses were assessed annually, and EDSS/MSSS measured at 5-year review. Determinants of MS conversion and relapse assessed by Cox regression, and disability progression by linear regression.

Results:IM history showed a strong positive trend with higher relapse risk (aHR=1.45,95%CI=0.97-2.16) but was not associated with MS conversion (aHR=0.92,95%CI=0.57-1.48). Anti-HHV-6 IgG titre>40 also showed strong positive trends with higher relapse (aHR=1.61,95%CI=0.99-2.63) and MS conversion risks (aHR=1.48,95%CI=0.89-2.46). Anti-HHV-6 IgG titre≥640 was significantly associated with higher MSSS (0.15(95%CI=0.00,0.30) and also showed a strong positive trend with higher EDSS 0.10(95%CI=-0.02,0.21). HHV-6 DNA detection showed strong positive trends with 83%(95%CI=-6-357) and 77%(95%CI=-4-328) higher MS conversion and relapse risk. Anti-EBV-EA-D IgG titre was associated with a lower annualised disability progression by EDSS (ptrend=0.037) and also showed strong positive trend with higher MSSS (ptrend=0.053). No associations were seen for other serological or viral load markers.

Conclusions:Overall, our data provides evidence that higher HHV-6 IgG was associated with increased risk of MS conversion and relapse but of borderline significance, and greater annualised disability progression, while that for EBV was more limited.

Funding

National Multiple Sclerosis Society

History

Publication title

Multiple Sclerosis and Related Disorders

Volume

59

Article number

103561

Number

103561

Pagination

1-9

ISSN

2211-0356

Department/School

Menzies Institute for Medical Research

Publisher

Elsevier B. V.

Place of publication

Amsterdam

Rights statement

© 2022 Elsevier B.V.

Repository Status

  • Restricted

Socio-economic Objectives

Prevention of human diseases and conditions

Usage metrics

    University Of Tasmania

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC