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Markers of Epstein-Barr virus and Human Herpesvirus-6 infection and multiple sclerosis clinical progression
Citation
Tao, C and Simpson-Yap, S and Taylor, B and Blizzard, L and Lucas, R and Ponsonby, AL and Broadley, S and van der Mei, I, AusLong/Ausimmune Investigators Group, Markers of Epstein-Barr virus and Human Herpesvirus-6 infection and multiple sclerosis clinical progression, Multiple Sclerosis and Related Disorders, 59 Article 103561. ISSN 2211-0356 (2022) [Refereed Article]
Copyright Statement
© 2022 Elsevier B.V.
DOI: doi:10.1016/j.msard.2022.103561
Abstract
Background:have been implicated in multiple sclerosis (MS) onset but little work has studied their relationships in early disease.
Objectives:Evaluate associations between markers of EBV and HHV-6 infection/reactivation and MS conversion, relapse and EDSS/MSSS amongst 205 CIS participants with EBV/HHV-6 data followed over 5 years.Method:Baseline serological and viral load measures of EBV and HHV-6 exposure/reactivation were measured and infectious mononucleosis (IM) history recorded. Conversion to MS and relapses were assessed annually, and EDSS/MSSS measured at 5-year review. Determinants of MS conversion and relapse assessed by Cox regression, and disability progression by linear regression.
Results:IM history showed a strong positive trend with higher relapse risk (aHR=1.45,95%CI=0.97-2.16) but was not associated with MS conversion (aHR=0.92,95%CI=0.57-1.48). Anti-HHV-6 IgG titre>40 also showed strong positive trends with higher relapse (aHR=1.61,95%CI=0.99-2.63) and MS conversion risks (aHR=1.48,95%CI=0.89-2.46). Anti-HHV-6 IgG titre≥640 was significantly associated with higher MSSS (0.15(95%CI=0.00,0.30) and also showed a strong positive trend with higher EDSS 0.10(95%CI=-0.02,0.21). HHV-6 DNA detection showed strong positive trends with 83%(95%CI=-6-357) and 77%(95%CI=-4-328) higher MS conversion and relapse risk. Anti-EBV-EA-D IgG titre was associated with a lower annualised disability progression by EDSS (ptrend=0.037) and also showed strong positive trend with higher MSSS (ptrend=0.053). No associations were seen for other serological or viral load markers.
Conclusions:Overall, our data provides evidence that higher HHV-6 IgG was associated with increased risk of MS conversion and relapse but of borderline significance, and greater annualised disability progression, while that for EBV was more limited.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Keywords: | first demyelinating event, conversion, relapse, Epstein-Barr virus, human herpesvirus-6, multiple sclerosis |
| Research Division: | Health Sciences |
| Research Group: | Epidemiology |
| Research Field: | Epidemiology not elsewhere classified |
| Objective Division: | Health |
| Objective Group: | Clinical health |
| Objective Field: | Prevention of human diseases and conditions |
| UTAS Author: | Tao, C (Mr Chunrong Tao) |
| UTAS Author: | Simpson-Yap, S (Dr Steve Simpson JR) |
| UTAS Author: | Taylor, B (Professor Bruce Taylor) |
| UTAS Author: | Blizzard, L (Professor Leigh Blizzard) |
| UTAS Author: | van der Mei, I (Professor Ingrid van der Mei) |
| ID Code: | 154298 |
| Year Published: | 2022 |
| Web of Science® Times Cited: | 1 |
| Deposited By: | Menzies Institute for Medical Research |
| Deposited On: | 2022-11-22 |
| Last Modified: | 2022-12-23 |
| Downloads: | 0 |
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