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Prospective dietary polyunsaturated fatty acid intake is associated with trajectories of fatty liver disease: an 8 year follow-up study from adolescence to young adulthood

Citation

Wan, F and Pan, Feng and Ayonrinde, O and Adams, LA and Mori, TA and Beilin, LJ and OSullivan, TA and Olynyk, JK and Oddy, WH, Prospective dietary polyunsaturated fatty acid intake is associated with trajectories of fatty liver disease: an 8 year follow-up study from adolescence to young adulthood, European journal of nutrition, 61, (8) pp. 3987-4000. ISSN 1436-6215 (2022) [Refereed Article]


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2022 The Author(s). Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/

DOI: doi:10.1007/s00394-022-02934-8

Abstract

Background and aim : Dietary fat intake has long been associated with fatty liver. Our study aimed to determine the effect of dietary fats on longitudinal fatty liver index (FLI) trajectories from adolescence to young adulthood.

Methods: Nine hundred eighty-five participants in the Raine Study, Perth, Western Australia, Australia, had cross-sectional assessments at ages 14, 17, 20 and 22 years, during which anthropometric measurements and blood tests were obtained. FLI trajectories were derived from the longitudinal FLI results. Dietary fat intake was measured with a semi-quantitative food frequency questionnaire at 14 years and log multinominal regression analyses were used to estimate relative risks.

Results:Three FLI trajectories were identified and labelled as stable-low (79.1%, N = 782), low-to-high (13.9%, N = 132), and stable-high (7%, N = 71). The low-to-high group associated with an increased intake of the long-chain polyunsaturated fatty acids EPA, DPA and DHA (RR 1.27, 95% CI 1.10-1.48) relative to the stable-low group. Compared to the stable-low group, omega-6 and the ratio of omega-6 to omega-3 in the stable-high group were associated with an increased relative risk of 1.34 (95% CI 1.02-1.76) and 1.10 (95% CI 1.03-1.16), respectively.

Conclusions: For those at high risk of fatty liver in early adolescence, high omega-6 fatty acid intake and a high ratio of omega-6 to omega-3 fatty acids are associated with increased risk of fatty liver. There should be caution in assuming these associations are causal due to possible undetected and underestimated confounding factors.

Item Details

Item Type:Refereed Article
Keywords:Fatty liver;Group-based trajectory modelling;Fatty liver index;Dietary fats
Research Division:Biomedical and Clinical Sciences
Research Group:Clinical sciences
Research Field:Gastroenterology and hepatology
Objective Division:Health
Objective Group:Clinical health
Objective Field:Diagnosis of human diseases and conditions
UTAS Author:Wan, F (Mr Fuzhen Wan)
UTAS Author:Pan, Feng (Dr Feng Pan)
UTAS Author:Oddy, WH (Professor Wendy Oddy)
ID Code:154260
Year Published:2022
Deposited By:Menzies Institute for Medical Research
Deposited On:2022-11-16
Last Modified:2022-12-20
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