Devine, MP and Ma, C and Tian, J and Antony, B and Cicuttini, F and Jones, G and Pan, F, Association of pain phenotypes with risk of falls and incident fractures, Biomedicines, 10, (11) Article 2924. ISSN 2227-9059 (2022) [Refereed Article]
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Methods:Data on 915 participants (mean age 63 years) from a population-based cohort study were studied at baseline and follow-ups at 2.6, 5.1 and 10.7 years. Three pain phenotypes were previously identified using the latent class analysis: Class 1: high prevalence of emotional problems and low prevalence of structural damage; Class 2: high prevalence of structural damage and low prevalence of emotional problems; Class 3: low prevalence of emotional problems and low prevalence of structural damage. Fractures were self-reported and falls risk score was measured using the Physiological Profile Assessment. Generalized estimating equations model and linear mixed-effects model were used to compare differences in incident fractures and falls risk score over 10.7 years between pain phenotypes, respectively.
Results:There were 3 new hip, 19 vertebral, and 121 non-vertebral fractures, and 138 any site fractures during 10.7-year follow-up. Compared with Class 3, Class 1 had a higher risk of vertebral (relative risk (RR) = 2.44, 95%CI: 1.22–4.91), non-vertebral fractures (RR = 1.20, 95%CI: 1.01–1.42), and any site fractures (RR = 1.24, 95%CI: 1.04–1.46) after controlling for covariates, bone mineral density and falls risk score. Class 2 had a higher risk of non-vertebral and any site fracture relative to those in Class 3 (non-vertebral: RR = 1.41, 95%CI: 1.17–1.71; any site: RR = 1.44, 95%CI: 1.20–1.73), but not vertebral fracture. Compared with Class 3, Class 1 had a higher falls risk score at baseline (β = 0.16, 95%CI: 0.09–0.23) and over 10.7-year (β = 0.03, 95%CI: 0.01–0.04).
Conclusions: Class 1 and/or Class 2 had a higher risk of incident fractures and falls risk score than Class 3, highlighting that targeted preventive strategies for fractures and falls are needed in pain population.
|Item Type:||Refereed Article|
|Keywords:||falls risk; incident fractures; pain phenotypes|
|Research Division:||Biomedical and Clinical Sciences|
|Research Group:||Clinical sciences|
|Objective Group:||Clinical health|
|Objective Field:||Prevention of human diseases and conditions|
|UTAS Author:||Devine, MP (Mr Maxim Devine)|
|UTAS Author:||Ma, C (Ms Canchen Ma)|
|UTAS Author:||Tian, J (Dr Jing Tian)|
|UTAS Author:||Antony, B (Dr Benny Eathakkattu Antony)|
|UTAS Author:||Jones, G (Professor Graeme Jones)|
|UTAS Author:||Pan, F (Dr Feng Pan)|
|Funding Support:||National Health and Medical Research Council (1157535)|
|Deposited By:||Menzies Institute for Medical Research|
|Downloads:||1 View Download Statistics|
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