eCite Digital Repository

Association of pain phenotypes with risk of falls and incident fractures

Citation

Devine, MP and Ma, C and Tian, J and Antony, B and Cicuttini, F and Jones, G and Pan, F, Association of pain phenotypes with risk of falls and incident fractures, Biomedicines, 10, (11) Article 2924. ISSN 2227-9059 (2022) [Refereed Article]


Preview
PDF (Published)
386Kb
  

Copyright Statement

2022. The Authors. Licensee MDPI, Basel, Switzerland. This article is licensed under a Creative Commons Attribution 4.0 International (CC BY 4.0) License (https://creativecommons.org/licenses/by/4.0/), which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

DOI: doi:10.3390/biomedicines10112924

Abstract

Objectives:To compare whether falls risk score and incident fracture over 10.7 years were different among three previously identified pain phenotypes.

Methods:Data on 915 participants (mean age 63 years) from a population-based cohort study were studied at baseline and follow-ups at 2.6, 5.1 and 10.7 years. Three pain phenotypes were previously identified using the latent class analysis: Class 1: high prevalence of emotional problems and low prevalence of structural damage; Class 2: high prevalence of structural damage and low prevalence of emotional problems; Class 3: low prevalence of emotional problems and low prevalence of structural damage. Fractures were self-reported and falls risk score was measured using the Physiological Profile Assessment. Generalized estimating equations model and linear mixed-effects model were used to compare differences in incident fractures and falls risk score over 10.7 years between pain phenotypes, respectively.

Results:There were 3 new hip, 19 vertebral, and 121 non-vertebral fractures, and 138 any site fractures during 10.7-year follow-up. Compared with Class 3, Class 1 had a higher risk of vertebral (relative risk (RR) = 2.44, 95%CI: 1.224.91), non-vertebral fractures (RR = 1.20, 95%CI: 1.011.42), and any site fractures (RR = 1.24, 95%CI: 1.041.46) after controlling for covariates, bone mineral density and falls risk score. Class 2 had a higher risk of non-vertebral and any site fracture relative to those in Class 3 (non-vertebral: RR = 1.41, 95%CI: 1.171.71; any site: RR = 1.44, 95%CI: 1.201.73), but not vertebral fracture. Compared with Class 3, Class 1 had a higher falls risk score at baseline (β = 0.16, 95%CI: 0.090.23) and over 10.7-year (β = 0.03, 95%CI: 0.010.04).

Conclusions: Class 1 and/or Class 2 had a higher risk of incident fractures and falls risk score than Class 3, highlighting that targeted preventive strategies for fractures and falls are needed in pain population.

Item Details

Item Type:Refereed Article
Keywords:falls risk; incident fractures; pain phenotypes
Research Division:Biomedical and Clinical Sciences
Research Group:Clinical sciences
Research Field:Pain
Objective Division:Health
Objective Group:Clinical health
Objective Field:Prevention of human diseases and conditions
UTAS Author:Devine, MP (Mr Maxim Devine)
UTAS Author:Ma, C (Ms Canchen Ma)
UTAS Author:Tian, J (Dr Jing Tian)
UTAS Author:Antony, B (Dr Benny Eathakkattu Antony)
UTAS Author:Jones, G (Professor Graeme Jones)
UTAS Author:Pan, F (Dr Feng Pan)
ID Code:154259
Year Published:2022
Funding Support:National Health and Medical Research Council (1157535)
Deposited By:Menzies Institute for Medical Research
Deposited On:2022-11-16
Last Modified:2022-12-23
Downloads:1 View Download Statistics

Repository Staff Only: item control page