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Associations between COVID-19 and hospitalisation with respiratory and non-respiratory conditions: a record linkage study


Rowe, SL and Leder, K and Dyson, K and Sundaresan, L and Wollersheim, D and Lynch, B and Abdullahi, I and Cowie, BC and Stephens, N and Nolan, TM and Sullivan, SG and Sutton, B and Cheng, AC, Associations between COVID-19 and hospitalisation with respiratory and non-respiratory conditions: a record linkage study, Medical Journal of Australia pp. 1-7. ISSN 1326-5377 (2022) [Refereed Article]

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Copyright Statement

2022 The Author(s). Medical journal of Australia published by John Wiley & Sons Australia, Ltd on behalf of AMPCo Pty Ltd. This is an open access article under the terms of the Creative Commons Attribution 4.0 International License, (CC BY 4.0)

DOI: doi:10.5694/mja2.51778


Objectives: To assess associations between SARS-CoV-2 infection and the incidence of hospitalisation with selected respiratory and non-respiratory conditions in a largely SARS-CoV-2 vaccine-naive population .

Design, setting, participants: Self-control case series; analysis of population-wide surveillance and administrative data for all laboratory-confirmed COVID-19 cases notified to the Victorian Department of Health (onset, 23 January 2020 - 31 May 2021; ie, prior to widespread vaccination rollout) and linked hospital admissions data (admission dates to 30 September 2021).

Main outcome measures: Hospitalisation of people with acute COVID-19; incidence rate ratios (IRRs) comparing incidence of hospitalisations with defined conditions (including cardiac, cerebrovascular, venous thrombo-embolic, coagulative, and renal disorders) from three days before to within 89 days of onset of COVID-19 with incidence during baseline period (60-365 days prior to COVID-19 onset).

Results: A total of 20 594 COVID-19 cases were notified; 2992 people (14.5%) were hospitalised with COVID-19. The incidence of hospitalisation within 89 days of onset of COVID-19 was higher than during the baseline period for several conditions, including myocarditis and pericarditis (IRR, 14.8; 95% CI, 3.2-68.3), thrombocytopenia (IRR, 7.4; 95% CI, 4.4-12.5), pulmonary embolism (IRR, 6.4; 95% CI, 3.6-11.4), acute myocardial infarction (IRR, 3.9; 95% CI, 2.6-5.8), and cerebral infarction (IRR, 2.3; 95% CI, 1.4-3.9).

Conclusions: SARS-CoV-2 infection is associated with higher incidence of hospitalisation with several respiratory and non-respiratory conditions. Our findings reinforce the value of COVID-19 mitigation measures such as vaccination, and awareness of these associations should assist the clinical management of people with histories of SARS-CoV-2 infection.

Item Details

Item Type:Refereed Article
Keywords:COVID-19, data linkage
Research Division:Health Sciences
Research Group:Epidemiology
Research Field:Epidemiology not elsewhere classified
Objective Division:Health
Objective Group:Public health (excl. specific population health)
Objective Field:Public health (excl. specific population health) not elsewhere classified
UTAS Author:Stephens, N (Associate Professor Nicola Stephens)
ID Code:154247
Year Published:2022
Deposited By:Medicine
Deposited On:2022-11-15
Last Modified:2023-01-13
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