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Effect of black tea on the dissolution profile of Lisinopril tablets


Obamiro, OK and Akinleye, MO and Oyetunde, OO, Effect of black tea on the dissolution profile of Lisinopril tablets, International Journal of Pharmacy and Pharmaceutical Sciences, 5, (Suppl 1) pp. 349-353. ISSN 0975-1491 (2013) [Refereed Article]

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Objective:The aim of the study is to determine the effect of Black tea on the dissolution profile of Lisinopril tablets.

Method: In vitro dissolution of Lisinopril tablets was studied in the absence of black tea as a control media and in the presence of black tea as a test media at pH 1.2, 4.5 & 6.8 (to simulate gastro intestinal condition) using USP apparatus II at 50rpm. 12 units were used according to USP specification and sampling was done at 5, 10, 15, 30, 45 and 60 minutes. Analysis of Lisinopril was done using High Performance Liquid Chromatography- coupled with ultra-violent detector.

Result: Results of the study showed that at pH 1.2, Black tea significantly decreased the dissolution of Lisinopril tablets (P = 0.0001). At pH 4.5 and 6.8 Black tea significantly increased the dissolution of Lisinopril tablets with (p = 0.004) and (p = 0.0007) respectively.

Conclusion: Co- administration of Lisinopril tablets and black tea among patients could lead to unpredictable and unexpected clinical effect, therefore health care personnel should encourage patients to take medication with portable water from credible sources and to space the consumption of beverages and administration of oral medications.

Item Details

Item Type:Refereed Article
Keywords:lisinopril dissolution, black tea, lisinopril, dissolution, cardiovascular disease
Research Division:Biomedical and Clinical Sciences
Research Group:Pharmacology and pharmaceutical sciences
Research Field:Pharmaceutical sciences
Objective Division:Manufacturing
Objective Group:Human pharmaceutical products
Objective Field:Human biological preventatives
UTAS Author:Obamiro, OK (Dr Kehinde Obamiro)
ID Code:154161
Year Published:2013
Deposited By:UTAS Centre for Rural Health
Deposited On:2022-11-04
Last Modified:2022-12-01

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