Cox, I and Campbell, JA and de Graaff, B and Corte, TJ and Moodley, Y and Hopkins, P and Macansh, S and Walter, HE and Palmer, AJ, P50 Comparison of the EQ-5D-5L and Aqol-8D in a cohort of people with idiopathic pulmonary fibrosis in Australia, The Future of HEOR in Patient-Driven Digital Healthcare Systems, 15-18 May 2022, Washington D.C, pp. S298. ISSN 1524-4733 (2022) [Conference Extract]
Background: Idiopathic pulmonary fibrosis (IPF) is a debilitating chronic lung disease with a high symptom burden, which has a substantial impact on health-related quality of life (HRQoL). Our study aimed to assess the performance of the EuroQol five-dimension (EQ-5D-5L) and the Assessment of Quality of Life- eight-dimension (AQoL-8D) questionnaires in measuring HRQoL as utility values (HSUVs) in an Australian IPF cohort.Objectives: Data were collected from participants of the Australian IPF Registry (AIPFR) using self-administered surveys which included the EQ-5D-5L and the AQoL-8D. Clinical data and disease specific HRQoL instruments were collected from the AIPFR. Performance of the two instruments was evaluated based on questionnaire practicality, agreement between the two instruments and test performance (internal and construct validity).
Results: Overall completion rates for the EQ-5D-5L and AQoL-8D were 96% and 85% respectively. Mean (median) HSUVs were 0.65 (0.70) and 0.69 (0.72) for the EQ-5D-5L and AQoL-8D respectively. There was reasonable agreement between the two instruments based on the Bland-Altman plot mean difference (-0.04) and intraclass correlation coefficient (0.84), however there were some differences. A larger range of values was observed with the EQ-5D-5L when compared to the AQOL-8D (-0.57-1.00 vs 0.16-1.00). The EQ-5D-5L had a greater divergent sensitivity and efficacy in relation to assessing HSUVs between clinical groupings. The AQoL-8D however had a higher sensitivity to measure psychosocial aspects of HRQoL in IPF.
Conclusions: The EQ-5D-5L exhibited better performance when compared to AQoL-8D in persons with IPF. This may be attributable to the high symptom burden which is physically debilitating to which the EQ-5D-5L may be more sensitive.
|Item Type:||Conference Extract|
|Keywords:||idiopathic pulmonary fibrosis, respiratory disease, health related qulaity of life, EQ5D, AQOL|
|Research Division:||Biomedical and Clinical Sciences|
|Research Group:||Cardiovascular medicine and haematology|
|Research Field:||Respiratory diseases|
|Objective Group:||Evaluation of health and support services|
|Objective Field:||Evaluation of health outcomes|
|UTAS Author:||Cox, I (Dr Ingrid Cox)|
|UTAS Author:||Campbell, JA (Dr Julie Campbell)|
|UTAS Author:||de Graaff, B (Dr Barbara de Graaff)|
|UTAS Author:||Walter, HE (Professor Haydn Walters)|
|UTAS Author:||Palmer, AJ (Professor Andrew Palmer)|
|Deposited By:||Menzies Institute for Medical Research|
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