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Association between radiographic hand osteoarthritis and bone microarchitecture in a population-based sample

Citation

Ma, C and Aitken, D and Wu, F and Squibb, K and Cicuttini, F and Jones, G, Association between radiographic hand osteoarthritis and bone microarchitecture in a population-based sample, Arthritis Research and Therapy, 24, (1) pp. 1-10. ISSN 1478-6362 (2022) [Refereed Article]


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The Author(s) 2022. Open Access This article is licensed under a Creative Commons Attribution 4.0 (CC BY 4.0) International License, (https://creativecommons.org/licenses/by/4.0/), which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made.

DOI: doi:10.1186/s13075-022-02907-6

Abstract

Background: Subchondral bone plays an important role in the pathogenesis of radiographic osteoarthritis (OA). However, the bony changes that occur in hand OA (HOA) are much less understood. This study aimed to describe the association between radiographic HOA and high-resolution peripheral quantitative computed tomography (HRpQCT) measures of the hand and radius in a population-based sample.

Methods: A total of 201 participants (mean age 72, 46% female) from the Tasmanian Older Adult Cohort (TASOAC) study underwent HRpQCT assessment of the 2nd distal and proximal interphalangeal (DIP, PIP), 1st carpometacarpal (CMC) joint, and distal radius. Radiographic HOA was assessed at the 2nd DIP, PIP joints, and the 1st CMC joint using the OARSI atlas.

Results: Proximal osteophyte and joint space narrowing (JSN) scores were consistently more strongly associated with HRpQCT measures compared to the distal site with positive associations for indices of bone size (total and trabecular bone area and cortical perimeter but inconsistent for cortical area) and negative associations for volumetric bone mineral density (vBMD). There was a decrease in trabecular number and bone volume fraction with increasing osteophyte and JSN score as well as an increase in trabecular separation and inhomogeneity. Osteophyte and JSN scores in the hand were not associated with HRpQCT measures at the distal radius.

Conclusions: This hypothesis generating data suggests that bone size and trabecular disorganization increase with both osteophyte formation and JSN (proximal more than distal), while local vBMD decreases. This process appears to be primarily at the site of pathology rather than nearby unaffected bone.

Item Details

Item Type:Refereed Article
Keywords:bone mineral density, bone size, HRpQCT, hand osteoarthritis, radiography
Research Division:Biomedical and Clinical Sciences
Research Group:Clinical sciences
Research Field:Rheumatology and arthritis
Objective Division:Health
Objective Group:Clinical health
Objective Field:Diagnosis of human diseases and conditions
UTAS Author:Ma, C (Ms Canchen Ma)
UTAS Author:Aitken, D (Associate Professor Dawn Aitken)
UTAS Author:Wu, F (Dr Feitong Wu)
UTAS Author:Squibb, K (Dr Kathryn Squibb)
UTAS Author:Jones, G (Professor Graeme Jones)
ID Code:154062
Year Published:2022
Deposited By:Menzies Institute for Medical Research
Deposited On:2022-10-27
Last Modified:2022-11-03
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