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A proinflammatory diet is associated with an increased likelihood of first clinical diagnosis of central nervous system demyelination in women
Methods: The 2003-2006 Ausimmune Study was a multicentre, matched, case-control study examining environmental risk factors for an FCD, a common precursor to MS. The DII is a well-recognised tool that categorises individuals' diets on a continuum from maximally anti-inflammatory to maximally pro-inflammatory. The DII score was calculated from dietary intake data collected using a food frequency questionnaire. Conditional logistic regression models were used to estimate the association between DII and FCD separately for men and women.
Results: In women, a higher DII score was associated with increased likelihood of FCD, with a 17% increase in likelihood of FCD per one-unit increase in DII score (adjusted odds ratio 1.17, 95% confidence interval 1.04-1.33). There was no association between DII and FCD in men (adjusted odds ratio 0.88, 95% confidence interval 0.73-1.07).
Conclusions: These findings suggest that a pro-inflammatory diet is associated with an increased likelihood of FCD in women.
Funding
National Multiple Sclerosis Society
History
Publication title
Multiple sclerosis and related disordersVolume
57Article number
103428Number
103428Pagination
1-6ISSN
2211-0356Department/School
Menzies Institute for Medical ResearchPublisher
Elsevier B. V.Place of publication
AmsterdamRights statement
© 2021 Elsevier B.V.Repository Status
- Restricted