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A proinflammatory diet is associated with an increased likelihood of first clinical diagnosis of central nervous system demyelination in women

Citation

Mannino, A and Lithander, FE and Dunlop, E and Hoare, S and Shivappa, N and Daly, A and Phillips, M and Pereira, G and Sherriff, J and Lucus, RM and Ponsonby, A-L and Hebert, JR and van der Mei, I and Black, LJ, Ausimmune Investigator Group, A proinflammatory diet is associated with an increased likelihood of first clinical diagnosis of central nervous system demyelination in women, Multiple sclerosis and related disorders, 57 Article 103428. ISSN 2211-0356 (2022) [Refereed Article]

Copyright Statement

Š 2021 Elsevier B.V.

DOI: doi:10.1016/j.msard.2021.103428

Abstract

Background: While a number of studies have examined associations between dietary factors and risk of multiple sclerosis (MS), little is known about intakes of inflammation-modulating foods and nutrients and risk of MS.

Objectives: To test associations between the Dietary Inflammatory Index (DIIŽ) and risk of a first clinical diagnosis of central nervous system (CNS) demyelination (FCD) (267 cases, 507 controls) using data from the Ausimmune Study.

Methods: The 2003-2006 Ausimmune Study was a multicentre, matched, case-control study examining environmental risk factors for an FCD, a common precursor to MS. The DII is a well-recognised tool that categorises individuals' diets on a continuum from maximally anti-inflammatory to maximally pro-inflammatory. The DII score was calculated from dietary intake data collected using a food frequency questionnaire. Conditional logistic regression models were used to estimate the association between DII and FCD separately for men and women.

Results: In women, a higher DII score was associated with increased likelihood of FCD, with a 17% increase in likelihood of FCD per one-unit increase in DII score (adjusted odds ratio 1.17, 95% confidence interval 1.04-1.33). There was no association between DII and FCD in men (adjusted odds ratio 0.88, 95% confidence interval 0.73-1.07).

Conclusions: These findings suggest that a pro-inflammatory diet is associated with an increased likelihood of FCD in women.

Item Details

Item Type:Refereed Article
Keywords:Multiple sclerosis, dietary patterns, Ausimmune Study, diet, nutrition, food
Research Division:Biomedical and Clinical Sciences
Research Group:Nutrition and dietetics
Research Field:Clinical nutrition
Objective Division:Health
Objective Group:Clinical health
Objective Field:Prevention of human diseases and conditions
UTAS Author:van der Mei, I (Professor Ingrid van der Mei)
ID Code:153972
Year Published:2022
Web of Science® Times Cited:3
Deposited By:Menzies Institute for Medical Research
Deposited On:2022-10-19
Last Modified:2023-01-04
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