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Combination of gait speed and grip strength to predict cognitive decline and dementia


Orchard, SG and Polekhina, G and Ryan, R and Raj, RC and Chong, TT-J and Lockery, JE and Ward, SA and Wolfe, R and Nelson, MR and Reid, CM and Murray, AM and Espinoza, SE and Newman, AB and McNeil, JJ and Collyer, TA and Callisaya, ML and Woods, RL, ASPREE Investigator group, Combination of gait speed and grip strength to predict cognitive decline and dementia, Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 14, (1) Article e12356. ISSN 2352-8729 (2022) [Refereed Article]

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©2022 The Authors. Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, LLC on behalf of Alzheimer’s Association. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) License, (, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

DOI: doi:10.1002/dad2.12353


Introduction:To determine whether slowed gait and weakened grip strength independently, or together, better identify risk of cognitive decline or dementia.

Methods:Time to walk 3 meters and grip strength were measured in a randomized placebo-controlled clinical trial involving community-dwelling, initially cognitively healthy older adults (N = 19,114).

Results:Over a median 4.7 years follow-up, slow gait and weak grip strength at baseline were independently associated with risk of incident dementia (hazard ratio[HR] = 1.44, 95% confidence interval [CI]: 1.19–1.73; and 1.24, 95% CI: 1.04–1.50, respectively) and cognitive decline (HR = 1.38, 95% CI: 1.26–1.51; and 1.04, 95% CI: 0.95–1.14, respectively) and when combined, were associated with 79% and 43% increase in risk of dementia and cognitive decline, respectively. Annual declines in gait and in grip over time showed similar results.

Discussion:Gait speed and grip strength are low-cost markers that may be useful in the clinical setting to help identify and manage individuals at greater risk, or with early signs, of dementia, particularly when measured together.

Item Details

Item Type:Refereed Article
Keywords:gait dementia frailty
Research Division:Biomedical and Clinical Sciences
Research Group:Clinical sciences
Research Field:Geriatrics and gerontology
Objective Division:Health
Objective Group:Specific population health (excl. Indigenous health)
Objective Field:Health related to ageing
UTAS Author:Nelson, MR (Professor Mark Nelson)
ID Code:153605
Year Published:2022
Deposited By:Menzies Institute for Medical Research
Deposited On:2022-09-27
Last Modified:2022-11-01
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