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On the magnetic nanoparticle injection strategy for hyperthermia treatment

Citation

Jiang, Q and Ren, F and Wang, C and Wang, Z and Kefayati, G and Kenjeres, S and Vafai, K and Liu, Y and Tang, H, On the magnetic nanoparticle injection strategy for hyperthermia treatment, International Journal of Mechanical Sciences, 235 Article 107707. ISSN 0020-7403 (2022) [Refereed Article]

Copyright Statement

Copyright 2022 Elsevier Ltd.

DOI: doi:10.1016/j.ijmecsci.2022.107707

Abstract

We developed a dedicated computational framework by coupling the lattice-Boltzmann-method (LBM) modeling and the particle-swarm-optimization (PSO) algorithm to search optimal strategies of magnetic nanoparticle (MNP) injection for hyperthermia-based cancer treatment. Two simplified tumor models were considered: a circular model representing geometrically regular tumors and an elliptic model representing geometrically irregular tumors, both sharing the same area. The temperature distribution in the tumor and its surrounding healthy tissue was predicted by solving the Pennes' bio-heat transfer equation (PBHTE). Both single- and multi-site injection strategies were explored. The results suggest that the multi-site injection strategies generally work well, while the single-site injection strategy fails even on the simplest circular tumor model. The more the injection sites, the better the performance. In particular, when the number of injection sites reaches eight, all temperature requirements can be nearly 100% satisfied in both tumor models. Whether or not including the minimum dose requirement in the objective function only affects the optimization results by less than 2%. The thermal dose was also assessed by considering both temperature and heat exposure time. It was found that the optimal multi-site injection strategies perform reasonably well for both tumor models. Although the setting is only two dimensional and the optimization is on very simplified tumor models, the framework adopted in this present study works well and can provide useful insights into magnetic hyperthermia treatment.

Item Details

Item Type:Refereed Article
Keywords:magnetic nanoparticle, hyperthermia, Lattice Boltzmann method
Research Division:Engineering
Research Group:Fluid mechanics and thermal engineering
Research Field:Computational methods in fluid flow, heat and mass transfer (incl. computational fluid dynamics)
Objective Division:Health
Objective Group:Clinical health
Objective Field:Treatment of human diseases and conditions
UTAS Author:Kefayati, G (Dr Gholamreza Kefayati)
ID Code:153506
Year Published:2022
Deposited By:Engineering
Deposited On:2022-09-21
Last Modified:2023-01-09
Downloads:0

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