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Survival of primary liver cancer for people from culturally and linguistically diverse backgrounds in Australia

Citation

Nguyen, ALT and Blizzard, CL and Yee, KC and Palmer, AJ and de Graaff, B, Survival of primary liver cancer for people from culturally and linguistically diverse backgrounds in Australia, Cancer Epidemiology, 81 Article 102252. ISSN 1877-7821 (2022) [Refereed Article]

Copyright Statement

2022 Elsevier Ltd

DOI: doi:10.1016/j.canep.2022.102252

Abstract

Background: Survival for Primary Liver Cancer (PLC) has been investigated in Australia, but limited work has been conducted on the burden for people with different socioeconomic status, region of residence, causes of PLC, and culturally and linguistically diverse (CALD) backgrounds. This study aimed to cover this gap in the literature by investigating PLC survival with the aforementioned factors.

Methods: This study linked four administrative datasets: Victorian Cancer Registry, Admitted Episodes Dataset, Emergency Minimum Dataset, and Death Index. The cohort was all cases with a PLC notification within the Victorian Cancer Registry between 01/01/2008 and 01/01/2016. The Kaplan-Meier method was used to estimate survival probabilities and the log-rank test was used to compare the difference in survival between subgroups. The Cox proportional hazard model was used to explore factors associated with PLC survival.

Results: The 1-, 3- and 5-year survival rates were 50.0%, 28.1% and 20.6%, respectively, with a median survival of 12.0 months (95% confidence interval (CI): 11.0-12.9 months). Higher survival was associated with younger age, hepatocellular carcinoma, and higher socio-economic status. People born in Asian, African, and American regions had higher survival than those born in Australia and New Zealand. Cases with viral hepatitis as an identified aetiology had higher survival than those whose PLC was related to alcohol consumption (hazard ratio=1.52, 95% CI: 1.19-1.96), diabetes and fatty liver disease (hazard ratio=1.35, 95% CI: 1.08-1.68).

Conclusion: Survival outcomes for people diagnosed with PLC were still poor and affected by many factors. Asian and African cases had better survival than Australian and New Zealand patients as PLC in Asian and African cases was mostly caused by viral hepatitis. Metropolitan areas were associated with a higher survival than rural areas, not only due to accessibility to surveillance and healthcare services but also because the majority of overseas-born patients reside in metropolitan areas.

Item Details

Item Type:Refereed Article
Keywords:liver cancer, mortality, survival, culturally and linguistically diverse
Research Division:Health Sciences
Research Group:Epidemiology
Research Field:Disease surveillance
Objective Division:Health
Objective Group:Public health (excl. specific population health)
Objective Field:Public health (excl. specific population health) not elsewhere classified
UTAS Author:Nguyen, ALT (Mr Le Tuan Anh Nguyen)
UTAS Author:Blizzard, CL (Professor Leigh Blizzard)
UTAS Author:Yee, KC (Dr Kwang Yee)
UTAS Author:Palmer, AJ (Professor Andrew Palmer)
UTAS Author:de Graaff, B (Dr Barbara de Graaff)
ID Code:153233
Year Published:2022
Deposited By:Menzies Institute for Medical Research
Deposited On:2022-09-14
Last Modified:2022-10-05
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