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Synthesis of 4-phenylthieno[2,3-c]quinolines via Suzuki-Miyaura cross-couplings

Citation

Hyland, IK and Ho, CC and Vuong, D and Tsai, YA and Lacey, E and Bissember, AC and Smith, JA, Synthesis of 4-phenylthieno[2,3-c]quinolines via Suzuki-Miyaura cross-couplings, ARKIVOC, 2022, (4) pp. 110-122. ISSN 1551-7012 (2022) [Refereed Article]


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© 2022. The Authors. This article is licensed under a Creative Commons Attribution 4.0 International (CC BY 4.0) License, (https://creativecommons.org/licenses/by/4.0/), which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

DOI: doi:10.24820/ark.5550190.p011.813

Abstract

A small library of previously unreported 4-phenylthieno[3,2-c]quinolines was prepared from a simple thiophene substrate via a modular synthetic strategy that exploited successive palladium-catalyzed crosscoupling reactions. These heterocycles were screened for activity against various bacterial, fungal, parasitic and cancer cell lines, which identified two original 4-(2-methoxyphenyl)-thieno[3,2-c]quinolines that display encouraging antibacterial activity.

Item Details

Item Type:Refereed Article
Keywords:thienoquinolines, Suzuki-Miyaura cross-coupling, heterocyclic chemistry, medicinal chemistry
Research Division:Chemical Sciences
Research Group:Organic chemistry
Research Field:Organic chemical synthesis
Objective Division:Expanding Knowledge
Objective Group:Expanding knowledge
Objective Field:Expanding knowledge in the chemical sciences
UTAS Author:Hyland, IK (Ms Isabel Hyland)
UTAS Author:Ho, CC (Dr Curtis Ho)
UTAS Author:Tsai, YA (Mr Yi An Tsai)
UTAS Author:Bissember, AC (Associate Professor Alex Bissember)
UTAS Author:Smith, JA (Professor Jason Smith)
ID Code:153193
Year Published:2022
Funding Support:Australian Research Council (FT200100049)
Deposited By:Chemistry
Deposited On:2022-09-13
Last Modified:2022-10-12
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