eCite Digital Repository

Synthesis of 4-phenylthieno[2,3-c]quinolines via Suzuki-Miyaura cross-couplings


Hyland, IK and Ho, CC and Vuong, D and Tsai, YA and Lacey, E and Bissember, AC and Smith, JA, Synthesis of 4-phenylthieno[2,3-c]quinolines via Suzuki-Miyaura cross-couplings, ARKIVOC, 2022, (4) pp. 110-122. ISSN 1551-7012 (2022) [Refereed Article]

PDF (Published)

Copyright Statement

2022. The Authors. This article is licensed under a Creative Commons Attribution 4.0 International (CC BY 4.0) License, (, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

DOI: doi:10.24820/ark.5550190.p011.813


A small library of previously unreported 4-phenylthieno[3,2-c]quinolines was prepared from a simple thiophene substrate via a modular synthetic strategy that exploited successive palladium-catalyzed crosscoupling reactions. These heterocycles were screened for activity against various bacterial, fungal, parasitic and cancer cell lines, which identified two original 4-(2-methoxyphenyl)-thieno[3,2-c]quinolines that display encouraging antibacterial activity.

Item Details

Item Type:Refereed Article
Keywords:thienoquinolines, Suzuki-Miyaura cross-coupling, heterocyclic chemistry, medicinal chemistry
Research Division:Chemical Sciences
Research Group:Organic chemistry
Research Field:Organic chemical synthesis
Objective Division:Expanding Knowledge
Objective Group:Expanding knowledge
Objective Field:Expanding knowledge in the chemical sciences
UTAS Author:Hyland, IK (Ms Isabel Hyland)
UTAS Author:Ho, CC (Dr Curtis Ho)
UTAS Author:Tsai, YA (Mr Yi An Tsai)
UTAS Author:Bissember, AC (Associate Professor Alex Bissember)
UTAS Author:Smith, JA (Professor Jason Smith)
ID Code:153193
Year Published:2022
Funding Support:Australian Research Council (FT200100049)
Deposited By:Chemistry
Deposited On:2022-09-13
Last Modified:2022-10-12
Downloads:7 View Download Statistics

Repository Staff Only: item control page