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Nanomaterial-assisted thread-based isotachophoresis with on-thread solute trapping

Citation

Chen, L and Ghiasvand, A and Sanz Rodriguez, E and Innis, PC and Paull, B, Nanomaterial-assisted thread-based isotachophoresis with on-thread solute trapping, Analyst, 147, (9) Article 1944. ISSN 0003-2654 (2022) [Refereed Article]

Copyright Statement

This journal is The Royal Society of Chemistry 2022

DOI: doi:10.1039/d2an00287f

Abstract

This research describes a nanomaterial-assisted thread-based isotachophoresis (TB-ITP) setup for the clean-up, preconcentration, and trapping of alkaloids (coptisine, berberine, and palmatine) in biological fluids, followed by their on-thread desorption electrospray ionization mass spectrometry (DESI-MS) determination. The reusable TB-ITP setup and a DESI compatible thread holder were 3D printed. A single nylon thread was employed as the ITP substrate for solute isolation and enrichment, and a short piece of graphene oxide (GO) functionalized nylon thread was tied around the main 'separation' thread as the 'trap' for the trapping of ITP focused alkaloids. Compared to the direct DESI-MS sample analysis, the sensitivity of the proposed method for the model solutes was increased up to 10-fold, benefiting from the TB-ITP focusing and enrichment strategy. This proof-of-concept use of nanomaterial-modified threads in electrofluidic separation and concentration procedures opens up a promising avenue to explore, particularly with regard to the sensitivity and selectivity of thread-based electrofluidic separation coupled with ambient ionization MS.

Item Details

Item Type:Refereed Article
Keywords:nanomaterial, thread-based isotachophoresis, solute trapping
Research Division:Chemical Sciences
Research Group:Analytical chemistry
Research Field:Separation science
Objective Division:Expanding Knowledge
Objective Group:Expanding knowledge
Objective Field:Expanding knowledge in the chemical sciences
UTAS Author:Chen, L (Miss Liang Chen)
UTAS Author:Ghiasvand, A (Professor Alireza Ghiasvand)
UTAS Author:Sanz Rodriguez, E (Dr Estrella Sanz Rodriguez)
UTAS Author:Paull, B (Professor Brett Paull)
ID Code:152988
Year Published:2022
Deposited By:Chemistry
Deposited On:2022-08-31
Last Modified:2023-01-23
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