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The clinical profile of NMOSD in Australia and New Zealand

Citation

Bukhari, W and Clarke, L and O'Gorman, C and Khalilidehkordi, E and Arnett, S and Prain, KM and Woodhall, M and Silvestrini, R and Bundell, CS and Ramanathan, S and Abernethy, D and Bhuta, S and Blum, S and Boggild, M and Boundy, K and Brew, BJ and Brownlee, W and Butzkueven, H and Carroll, WM and Chen, C and Coulthard, A and Dale, RC and Das, C and Dear, K and Fabis-Pedrini, MJ and Fulcher, D and Gillis, D and Hawke, S and Heard, R and Henderson, APD and Heshmat, S and Hodgkinson, S and Jimenez-Sanchez, S and Kilpatrick, TJ and King, J and Kneebone, C and Kornberg, AJ and Lechner-Scott, J and Lin, MW and Lynch, C and Macdonnell, RAL and Mason, DF and McCombe, PA and Pereira, J and Pollard, JD and Reddel, SW and Shaw, C and Spies, J and Stankovich, J and Sutton, I and Vucic, S and Walsh, M and Wong, RC and Yiu, EM and Barnett, MH and Kermode, AG and Marriott, MP and Parratt, J and Slee, M and Taylor, BV and Willoughby, E and Wilson, RJ and Brilot, F and Vincent, A and Waters, P and Broadley, SA, The clinical profile of NMOSD in Australia and New Zealand, Journal of Neurology, 267, (5) pp. 1431-1443. ISSN 0340-5354 (2020) [Refereed Article]

Copyright Statement

Springer-Verlag GmbH Germany, part of Springer Nature 2020.

DOI: doi:10.1007/s00415-020-09716-4

Abstract

Neuromyelitis optica spectrum disorders (NMOSD) are an inflammation of the central nervous system associated with autoantibodies to aquaporin-4. We have undertaken a clinic-based survey of NMOSD in the Australia and New Zealand populations with the aim of characterising the clinical features and establishing the value of recently revised diagnostic criteria. Cases of possible NMOSD and age and sex-matched controls with multiple sclerosis (MS) were referred from centres across Australia and New Zealand. Cases were classified as NMOSD if they met the 2015 IPND criteria and remained as suspected NMOSD if they did not. Clinical and paraclinical data were compared across the three groups. NMOSD was confirmed in 75 cases and 89 had suspected NMOSD. There were 101 controls with MS. Age at onset, relapse rates and EDSS scores were significantly higher in NMOSD than in MS. Lesions and symptoms referable to the optic nerve were more common in NMOSD whereas brainstem, cerebellar and cerebral lesions were more common in MS. Longitudinally extensive spinal cord lesions were seen in 48/71 (68%) of cases with NMOSD. Elevations of CSF, white cell count and protein were more common in NMOSD. We have confirmed a clinical pattern of NMOSD that has been seen in several geographical regions. We have demonstrated the clinical utility of the current diagnostic criteria. Distinct patterns of disease are evident in NMOSD and MS, but there remains a large number of patients with NMOSD-like features who do not meet the current diagnostic criteria for NMOSD and remain a diagnostic challenge.

Item Details

Item Type:Refereed Article
Keywords:neuromyelitis optica, clinical features, multiple sclerosis, aquaporin, autoimmune disease
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Neurology and neuromuscular diseases
Objective Division:Health
Objective Group:Clinical health
Objective Field:Diagnosis of human diseases and conditions
UTAS Author:Stankovich, J (Dr Jim Stankovich)
ID Code:152871
Year Published:2020
Web of Science® Times Cited:14
Deposited By:Research Performance and Analysis
Deposited On:2022-08-25
Last Modified:2022-11-17
Downloads:0

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