152870 - Transmissable cancers in an.pdf (1.34 MB)
Transmissible cancers in an evolutionary perspective
journal contribution
posted on 2023-05-21, 13:01 authored by Dujon, AM, Gatenby, RA, Bramwell, G, MacDonald, N, Dohrmann, E, Raven, N, Schultz, A, Rodrigo Hamede RossRodrigo Hamede Ross, Gerard, AL, Giraudeau, M, Thomas, F, Ujvari, BInter-individual transmission of cancer cells represents an intriguing and unexplored host-pathogen system, with significant ecological and evolutionary ramifications. The pathogen consists of clonal malignant cell lines that spread horizontally as allografts and/or xenografts. Although only nine transmissible cancer lineages in eight host species from both terrestrial and marine environments have been investigated, they exhibit evolutionary dynamics that may provide novel insights into tumor-host interactions particularly in the formation of metastases. Here we present an overview of known transmissible cancers, discuss the necessary and sufficient conditions for cancer transmission, and provide a comprehensive review on the evolutionary dynamics between transmissible cancers and their hosts.
History
Publication title
iScienceVolume
23Issue
7Article number
101269Number
101269Pagination
1-12ISSN
2589-0042Department/School
School of Natural SciencesPublisher
Cell PressPlace of publication
United StatesRights statement
2020 The Author(s). This is an open access article under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) license (http://creativecommons.org/licenses/by-nc-nd/4.0/).Repository Status
- Open