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Transmissible cancers in an evolutionary perspective

Citation

Dujon, AM and Gatenby, RA and Bramwell, G and MacDonald, N and Dohrmann, E and Raven, N and Schultz, A and Hamede, R and Gerard, AL and Giraudeau, M and Thomas, F and Ujvari, B, Transmissible cancers in an evolutionary perspective, iScience, 23, (7) Article 101269. ISSN 2589-0042 (2020) [Refereed Article]


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Copyright Statement

2020 The Author(s). This is an open access article under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

DOI: doi:10.1016/j.isci.2020.101269

Abstract

Inter-individual transmission of cancer cells represents an intriguing and unexplored host-pathogen system, with significant ecological and evolutionary ramifications. The pathogen consists of clonal malignant cell lines that spread horizontally as allografts and/or xenografts. Although only nine transmissible cancer lineages in eight host species from both terrestrial and marine environments have been investigated, they exhibit evolutionary dynamics that may provide novel insights into tumor-host interactions particularly in the formation of metastases. Here we present an overview of known transmissible cancers, discuss the necessary and sufficient conditions for cancer transmission, and provide a comprehensive review on the evolutionary dynamics between transmissible cancers and their hosts.

Item Details

Item Type:Refereed Article
Keywords:biological sciences, evolutionary biology, evolutionary ecology, cancer
Research Division:Biological Sciences
Research Group:Genetics
Research Field:Genomics
Objective Division:Expanding Knowledge
Objective Group:Expanding knowledge
Objective Field:Expanding knowledge in the biological sciences
UTAS Author:Hamede, R (Dr Rodrigo Hamede Ross)
UTAS Author:Ujvari, B (Dr Beata Ujvari)
ID Code:152870
Year Published:2020
Web of Science® Times Cited:23
Deposited By:Research Performance and Analysis
Deposited On:2022-08-25
Last Modified:2022-09-07
Downloads:3 View Download Statistics

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