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Transmissible cancers in an evolutionary perspective
Citation
Dujon, AM and Gatenby, RA and Bramwell, G and MacDonald, N and Dohrmann, E and Raven, N and Schultz, A and Hamede, R and Gerard, AL and Giraudeau, M and Thomas, F and Ujvari, B, Transmissible cancers in an evolutionary perspective, iScience, 23, (7) Article 101269. ISSN 2589-0042 (2020) [Refereed Article]
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Copyright Statement
2020 The Author(s). This is an open access article under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
DOI: doi:10.1016/j.isci.2020.101269
Abstract
Inter-individual transmission of cancer cells represents an intriguing and unexplored host-pathogen system, with significant ecological and evolutionary ramifications. The pathogen consists of clonal malignant cell lines that spread horizontally as allografts and/or xenografts. Although only nine transmissible cancer lineages in eight host species from both terrestrial and marine environments have been investigated, they exhibit evolutionary dynamics that may provide novel insights into tumor-host interactions particularly in the formation of metastases. Here we present an overview of known transmissible cancers, discuss the necessary and sufficient conditions for cancer transmission, and provide a comprehensive review on the evolutionary dynamics between transmissible cancers and their hosts.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Keywords: | biological sciences, evolutionary biology, evolutionary ecology, cancer |
| Research Division: | Biological Sciences |
| Research Group: | Genetics |
| Research Field: | Genomics |
| Objective Division: | Expanding Knowledge |
| Objective Group: | Expanding knowledge |
| Objective Field: | Expanding knowledge in the biological sciences |
| UTAS Author: | Hamede, R (Dr Rodrigo Hamede Ross) |
| UTAS Author: | Ujvari, B (Dr Beata Ujvari) |
| ID Code: | 152870 |
| Year Published: | 2020 |
| Web of Science® Times Cited: | 23 |
| Deposited By: | Research Performance and Analysis |
| Deposited On: | 2022-08-25 |
| Last Modified: | 2022-09-07 |
| Downloads: | 3 View Download Statistics |
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