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Rare and unique adaptations to cancer in domesticated species: An untapped resource?

Citation

Thomas, F and Giraudeau, M and Dheilly, NM and Gouzerh, F and Boutry, J and Beckmann, C and Biro, PA and Hamede, R and Abadie, J and Labrut, S and Bieuville, M and Misse, D and Bramwell, G and Schultz, A and Le Loc'h, G and Vincze, O and Roche, B and Renaud, F and Russell, T and Ujvari, B, Rare and unique adaptations to cancer in domesticated species: An untapped resource?, Evolutionary Applications, 13, (7) pp. 1605-1614. ISSN 1752-4571 (2020) [Refereed Article]

Copyright Statement

2020 The Authors. Evolutionary Applications published by John Wiley & Sons Ltd This is an open access article under the terms of the Creative Commons Attribution 4.0 International (CC BY 4.0) License, (https://creativecommons.org/licenses/by/4.0/) which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

DOI: doi:10.1111/eva.12920

Abstract

Strong and ongoing artificial selection in domestic animals has resulted in amazing phenotypic responses that benefit humans, but often at a cost to an animal's health, and problems related to inbreeding depression, including a higher incidence of cancer. Despite high rates of cancer in domesticated species, little attention has been devoted to exploring the hypothesis that persistent artificial selection may also favour the evolution of compensatory anticancer defences. Indeed, there is evidence for effective anti-cancer defences found in several domesticated species associated with different cancer types. We also suggest that artificial selection can favour the "domestication" of inherited oncogenic mutations in rare instances, retaining those associated to late and/or less aggressive cancers, and that by studying these seemingly rare anticancer adaptations, novel cancer treatments may be found.

Item Details

Item Type:Refereed Article
Keywords:cancer, domestication domestication syndrome, evolution evolutionary mismatch selection, spontaneous regression, cutaneous melanomas, bladder cancer, homozygosity, tumors, leukemia, animals, genomes, disease
Research Division:Biological Sciences
Research Group:Ecology
Research Field:Population ecology
Objective Division:Environmental Management
Objective Group:Terrestrial systems and management
Objective Field:Terrestrial biodiversity
UTAS Author:Hamede, R (Dr Rodrigo Hamede Ross)
UTAS Author:Ujvari, B (Dr Beata Ujvari)
ID Code:152868
Year Published:2020
Web of Science® Times Cited:6
Deposited By:Medicine
Deposited On:2022-08-25
Last Modified:2022-09-08
Downloads:0

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