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Modest decrease in severity of obesity in adolescence associates with low arterial stiffness


Saner, C and Laitinen, TT and Nuotio, J and Arnup, SJ and Harcourt, BE and Bekkering, S and McCallum, Z and Kao, KT and Janner, M and Magnussen, CG and Sabin, MA and Juonala, M and Burgner, DP, Modest decrease in severity of obesity in adolescence associates with low arterial stiffness, Atherosclerosis, 335 pp. 23-30. ISSN 0021-9150 (2021) [Refereed Article]

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Copyright Statement

2021 The Authors. Published by Elsevier B.V. This is an open access article under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) license (

DOI: doi:10.1016/j.atherosclerosis.2021.09.013


Childhood obesity is associated with cardiovascular risk factors (CVRF), subclinical cardiovascular phenotypes (carotid intima-media thickness, cIMT; pulse-wave velocity, PWV; and carotid elasticity), and adult cardiovascular disease (CVD) mortality. In youth with obesity (body mass index, BMI ≥95th centile), we investigated associations between changes in adiposity and CVRF in early adolescence and subclinical cardiovascular phenotypes in late adolescence.

Participants had adiposity measures (the severity of obesity in percentage >95th BMI-centile (%>95th BMI-centile)), waist circumference (WC), percentage total body fat (%BF) and CVRF (systolic blood pressure, SBP; glycoprotein acetyls, GlycA; and low-density lipoprotein cholesterol) assessed in early (mean age 10.2+-3.5y) and late (15.7+-3.7y) adolescence. Subclinical cardiovascular phenotypes were assessed in late adolescence. Multivariable regression analysis was performed.

Results Decreasing the %>95th BMI-centile was associated with carotid elasticity (0.945%/10 mmHg, p = 0.002) in females, and with PWV in males (-0.75 m/s, p < 0.001). Changes in all adiposity measures (per 1-unit increase) were associated with carotid elasticity (-0.020 to -0.063%/10 mmHg, p < 0.005), and PWV (0.011-0.045 m/s, p < 0.005). Changes in GlycA (per 50mol-increase) were associated with elasticity (-0.162%/10 mmHg, p = 0.042), and changes in SBP (per 10 mmHg-increase) were associated with PWV (0.260 m/s, p < 0.001). Adjusted for change in BMI, the coefficient for GlycA was reduced by 46% and for SBP by 12%. Only male sex was associated with cIMT (+34 m, p = 0.006).

Conclusions In youth with obesity, decreasing or maintaining the severity of obesity, and decreasing the levels of SBP and GlycA from early to late adolescence was associated with low arterial stiffness.

Item Details

Item Type:Refereed Article
Keywords:pediatrics; obesity; inflammation; arterial stiffness; arterial injury
Research Division:Health Sciences
Research Group:Epidemiology
Research Field:Epidemiology not elsewhere classified
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:McCallum, Z (Dr Zoe McCallum)
UTAS Author:Magnussen, CG (Associate Professor Costan Magnussen)
ID Code:152820
Year Published:2021
Web of Science® Times Cited:1
Deposited By:Menzies Institute for Medical Research
Deposited On:2022-08-24
Last Modified:2022-09-13
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