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Frontal analysis capillary electrophoresis: recent advances and future perspectives


Romano JR, EF and Quirino, JP, Frontal analysis capillary electrophoresis: recent advances and future perspectives, Bioanalysis, 10, (14) pp. 1143-1159. ISSN 1757-6180 (2018) [Refereed Article]

DOI: doi:10.4155/bio-2018-0051


The developments on frontal analysis capillary electrophoresis (FACE) from 2012 to 2017 to study interactions of simple and complex systems are reviewed. Most research papers focused on therapeutic drug-related studies; however, other studies include chemical sensing, drug delivery, inhibitor screening and capillary coating. New ligand-substrate systems such as template-molecularly imprinted polymer systems were reported. Comparison of FACE with other analytical techniques used to investigate binding interaction, and the determination of binding parameters using different isotherm models are also covered. In 2017, eight research papers were reported including new detection by ESI-MS. Future research direction of FACE may include high sensitivity detection and throughput screening of drugs, natural products and biomarkers for clinical diagnosis.

Item Details

Item Type:Refereed Article
Keywords:binding parameters; capillary coating; frontal analysis capillary electrophoresis; ligand-substrate interaction; method of detection
Research Division:Biomedical and Clinical Sciences
Research Group:Pharmacology and pharmaceutical sciences
Research Field:Pharmacogenomics
Objective Division:Health
Objective Group:Clinical health
Objective Field:Diagnosis of human diseases and conditions
UTAS Author:Quirino, JP (Associate Professor Lito Quirino)
ID Code:152802
Year Published:2018
Web of Science® Times Cited:6
Deposited By:Medicine
Deposited On:2022-08-24
Last Modified:2022-09-13

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