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Immune responses to SARS-CoV-2 in three children of parents with symptomatic COVID-19

Citation

Tosif, S and Neeland, MR and Sutton, P and Licciardi, PV and Sarkar, S and Selva, KJ and Do, LAH and Donato, C and Toh, ZQ and Higgins, R and Van de Sandt, C and Lemke, MM and Lee, CY and Shoffner, SK and Flanagan, KL and Arnold, KB and Mordant, FL and Mulholland, K and Bines, J and Dohle, K and Pellicci, DG and Curtis, N and McNab, S and Steer, A and Saffery, R and Subbarao, K and Chung, AW and Kedzierska, K and Burgner, DP and Crawford, NW, Immune responses to SARS-CoV-2 in three children of parents with symptomatic COVID-19, Nature Communications, 11, (1) Article 5703. ISSN 2041-1723 (2020) [Refereed Article]


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DOI: doi:10.1038/s41467-020-19545-8

Abstract

Compared to adults, children with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have predominantly mild or asymptomatic infections, but the underlying immunological differences remain unclear. Here, we describe clinical features, virology, longitudinal cellular, and cytokine immune profile, SARS-CoV-2-specific serology and salivary antibody responses in a family of two parents with PCR-confirmed symptomatic SARS-CoV-2 infection and their three children, who tested repeatedly SARS-CoV-2 PCR negative. Cellular immune profiles and cytokine responses of all children are similar to their parents at all timepoints. All family members have salivary anti-SARS-CoV-2 antibodies detected, predominantly IgA, that coincide with symptom resolution in 3 of 4 symptomatic members. Plasma from both parents and one child have IgG antibody against the S1 protein and virus-neutralizing activity detected. Using a systems serology approach, we demonstrate higher levels of SARS-CoV-2-specific antibody features of these family members compared to healthy controls. These data indicate that children can mount an immune response to SARS-CoV-2 without virological confirmation of infection, raising the possibility that immunity in children can prevent the establishment of SARS-CoV-2 infection. Relying on routine virological and serological testing may not identify exposed children, with implications for epidemiological and clinical studies across the life-span. Children with SARS-CoV-2 infection are more likely to have mild symptoms and may be asymptomatic, but underlying reasons remain unclear. Here, the authors show cellular, cytokine and antibody response to SARS-CoV-2 infection in three children who repeatedly tested negative for the virus by PCR, despite high exposure in the household.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Immunology
Research Field:Immunology not elsewhere classified
Objective Division:Expanding Knowledge
Objective Group:Expanding knowledge
Objective Field:Expanding knowledge in the biological sciences
UTAS Author:Flanagan, KL (Dr Katie Flanagan)
ID Code:152788
Year Published:2020
Web of Science® Times Cited:54
Deposited By:Mathematics
Deposited On:2022-08-24
Last Modified:2022-08-24
Downloads:0

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