eCite Digital Repository

Effect of atorvastatin on knee cartilage volume in patients with symptomatic knee osteoarthritis: results from a randomized placebo-controlled trial

Citation

Wang, Y and Jones, Graeme and Hill, C and Wluka, AE and Forbes, AB and Tonkin, AM and Hussain, SM and Ding, C, Effect of atorvastatin on knee cartilage volume in patients with symptomatic knee osteoarthritis: results from a randomized placebo-controlled trial, Arthritis and Rheumatology, 73, (11) pp. 2035-2043. ISSN 2326-5191 (2021) [Refereed Article]

DOI: doi:10.1002/art.41760

Abstract

Objective To determine whether atorvastatin slows tibial cartilage volume loss in patients with symptomatic knee osteoarthritis (OA) in a multicenter, randomized, double-blind, placebo-controlled trial. Methods Participants ages 40-70 years were randomized to receive oral atorvastatin (40 mg once daily) (n = 151) or matching placebo (n = 153). The primary end point was annual percentage change in tibial cartilage volume over 2 years, assessed using magnetic resonance imaging (MRI). The prespecified secondary end points were progression of cartilage defects and bone marrow lesions over 2 years, which were assessed using MRI and change in Western Ontario and McMaster Universities Osteoarthritis (WOMAC) Index pain, stiffness, and function scores. Results A total of 248 of 304 participants (81.6%) completed the trial (mean age 55.7 years; 55.6% women). The annual change in tibial cartilage volume differed minimally between the atorvastatin and placebo groups (mean change -1.66% versus -2.17%, between-group difference 0.50% [95% confidence interval (95% CI) -0.17%, 1.17%]). There were no significant differences in the progression of cartilage defects (odds ratio [OR] 0.86 [95% CI 0.52, 1.41]) or progression of bone marrow lesions (OR 1.00 [95% CI 0.62, 1.63]). Moreover, there were no significant differences in change in WOMAC pain, stiffness, or function scores over 2 years between the atorvastatin and placebo groups (mean change in pain score -36.0 versus -29.5, adjusted difference -2.7 [95% CI -27.1, 21.7]; mean change in stiffness score -14.2 versus -11.8, adjusted difference -0.2 [95% CI -12.2, 11.8]; mean change in function score -89.4 versus -87.5, adjusted difference 0.3 [95% CI -83.1, 83.6]). The incidence of adverse events (AEs) was similar between the atorvastatin and placebo groups (57 [37.7%] versus 52 [34.0%] experiencing AEs). Conclusion Treatment with oral atorvastatin (40 mg once daily), compared to placebo, did not significantly reduce cartilage volume loss over 2 years in patients with symptomatic knee OA. These findings do not support the use of atorvastatin for the treatment of knee OA.

Item Details

Item Type:Refereed Article
Keywords:statin use, radiographic osteoarthritis, progressi
Research Division:Health Sciences
Research Group:Epidemiology
Research Field:Epidemiology not elsewhere classified
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Wang, Y (Ms Yuanyuan Wang)
UTAS Author:Jones, Graeme (Professor Graeme Jones)
UTAS Author:Hill, C (Associate Professor Catherine Hill)
UTAS Author:Wluka, AE (Ms Anita Wluka)
UTAS Author:Tonkin, AM (Professor Andrew Tonkin)
UTAS Author:Ding, C (Professor Chang-Hai Ding)
ID Code:152783
Year Published:2021
Web of Science® Times Cited:2
Deposited By:Menzies Institute for Medical Research
Deposited On:2022-08-24
Last Modified:2022-08-24
Downloads:0

Repository Staff Only: item control page