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Persistence of Adverse drug reaction-related hospitalization risk following discharge


Schmid, O and Bereznicki, B and Peterson, GM and Stankovich, J and Bereznicki, L, Persistence of Adverse drug reaction-related hospitalization risk following discharge, International journal of environmental research and public health, 9, (19) Article 5585. ISSN 1660-4601 (2022) [Refereed Article]


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Copyright 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://

DOI: doi:10.3390/ijerph19095585


This retrospective cohort study analyzed the administrative hospital records of 91,500 patients with the aim of assessing adverse drug reaction (ADR)-related hospital admission risk after discharge from ADR and non-ADR-related admission. Patients aged ≥18 years with an acute admission to public hospitals in Tasmania, Australia between 2011 and 2015 were followed until May 2017. The index admissions (n = 91,550) were stratified based on whether they were ADR-related (n = 2843, 3.1%) or non-ADR-related (n = 88,707, 96.9%). Survival analysis assessed the post-index ADR-related admission risk using (1) the full dataset, and (2) a matched subset of patients using a propensity score analysis. Logistic regression was used to identify the risk factors for ADR-related admissions within 90 days of post-index discharge. The patients with an ADR-related index admission were almost five times more likely to experience another ADR-related admission within 90 days (p < 0.001). An increased risk persisted for at least 5 years (p < 0.001), which was substantially longer than previously reported. From the matched subset of patients, the risk of ADR-related admission within 90 and 365 days more than doubled in the patients with an ADR-related index admission (p < 0.0001). These admissions were often attributed to the same drug class as the patients' index ADR-related admission. Cancer was a major risk factor for ADR-related re-hospitalization within 90 days; other factors included heart failure and increasing age.

Item Details

Item Type:Refereed Article
Keywords:adverse drug reactions; medication errors; medication safety; adverse drug event; hospital admission; risk factors
Research Division:Biomedical and Clinical Sciences
Research Group:Pharmacology and pharmaceutical sciences
Research Field:Clinical pharmacology and therapeutics
Objective Division:Health
Objective Group:Clinical health
Objective Field:Efficacy of medications
UTAS Author:Schmid, O (Ms Olive Schmid)
UTAS Author:Bereznicki, B (Dr Bonnie Bereznicki)
UTAS Author:Peterson, GM (Professor Gregory Peterson)
UTAS Author:Stankovich, J (Dr Jim Stankovich)
UTAS Author:Bereznicki, L (Professor Luke Bereznicki)
ID Code:152766
Year Published:2022
Deposited By:Medicine
Deposited On:2022-08-24
Last Modified:2022-09-20
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