Bile salts are naturally occurring chiral surfactants that are able to solubilize hydrophobic compounds. Because of this ability, bile salts were exploited as chiral selectors added to the background solution (BGS) in the chiral micellar electrokinetic chromatography (MEKC) of various small molecules. In this review, we aimed to examine the developments in research on chiral MEKC using bile salts as chiral selectors over the past 20 years. The review begins with a discussion of the aggregation of bile salts in chiral recognition and separation, followed by the use of single bile salts and bile salts with other chiral selectors (i.e., cyclodextrins, proteins and single-stranded DNA aptamers). Advanced techniques such as partial-filling MEKC, stacking and single-drop microextraction were considered. Potential applications to real samples, including enantiomeric impurity analysis, were also discussed.

Item Type:	Refereed Article
Keywords:	bile salts, capillary electrophoresis, chiral selector, chiral separation, electrokinetic chromatography, surfactants
Research Division:	Chemical Sciences
Research Group:	Medicinal and biomolecular chemistry
Research Field:	Biologically active molecules
Objective Division:	Environmental Management
Objective Group:	Fresh, ground and surface water systems and management
Objective Field:	Surface water quantification, allocation and impact of depletion
UTAS Author:	Yu, RB (Mr Raymond Fernando Yu)
UTAS Author:	Quirino, JP (Associate Professor Lito Quirino)
ID Code:	152703
Year Published:	2021
Web of Science® Times Cited:	3
Deposited By:	Medicine
Deposited On:	2022-08-23
Last Modified:	2022-09-07
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