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Metabolomics as a functional tool in screening gastro intestinal diseases: Where are we in High Throughput Screening?


Gundamaraju, R and Vemuri, R and Eri, R and Ishiki, HM and Coy-Barrera, E and Yarla, NS and Dos Santos, SG and Alves, MF and Filho, JMB and Diniz, MFFM and Scotti, MT and Scotti, L, Metabolomics as a functional tool in screening gastro intestinal diseases: Where are we in High Throughput Screening?, Combinatorial Chemistry and High Throughput Screening, 20, (3) pp. 247-254. ISSN 1386-2073 (2017) [Refereed Article]

DOI: doi:10.2174/1386207319666161220122903


Identifying novel bio markers in gastro intestinal disease is a promising method where a comprehensive analysis of the metabolome is performed. Metabolomics has evolved enormously in the past decade, paving a path in gastro intestinal disease research, especially diseases which lead to high morbidity and mortality. Metabolomics involves identifying metabolites such as anti-oxidants, and amino acids etc., which are screened in the urine, feces and tissue samples. Certain cases employ advanced tools like GC-MS, 1HNMR and GC-MS/SPME which reveal valuable information concerning disease severity and differentiation. In light of escalating health care costs and risky invasive procedures, metabolomics can be chosen as a safe yet precise method for screening diseases like ulcerative colitis, Crohns' disease, celiac disease, and gastro intestinal cancers. The present review focuses on major advancements in gastro intestinal metabolomics, giving attention to which parameters are assessed, and to recent changes in metabolite analysis.

Item Details

Item Type:Refereed Article
Keywords:Celiac disease; Crohns' disease; Metabolomics; Ulcerative colitis; analysis; gastrointestinal disorders; inflammatory bowel disease; metabolites
Research Division:Biological Sciences
Research Group:Bioinformatics and computational biology
Research Field:Proteomics and metabolomics
Objective Division:Health
Objective Group:Clinical health
Objective Field:Treatment of human diseases and conditions
UTAS Author:Gundamaraju, R (Mr Rohit Gundamaraju)
UTAS Author:Vemuri, R (Mr Ravichandra Vemuri)
UTAS Author:Eri, R (Associate Professor Raj Eri)
ID Code:152650
Year Published:2017
Web of Science® Times Cited:4
Deposited By:Health Sciences
Deposited On:2022-08-23
Last Modified:2022-09-13

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