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Targeting eosinophils in respiratory diseases: Biological axis, emerging therapeutics and treatment modalities

Citation

Lee, LY and Hew, GSY and Mehta, M and Shukla, SD and Satija, S and Khurana, N and Anand, K and Dureja, H and Singh, SK and Mishra, V and Singh, PK and Gulati, M and Prasher, P and Aljabali, AAA and Tambuwala, MM and Thangavelu, L and Panneerselvam, J and Gupta, G and Zacconi, FC and Shastri, M and Jha, NK and Xenaki, D and MacLoughlin, R and Oliver, BG and Chellappan, DK and Dua, K, Targeting eosinophils in respiratory diseases: Biological axis, emerging therapeutics and treatment modalities, Life Sciences, 267 pp. 1-26. ISSN 0024-3205 (2021) [Refereed Article]

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Copyright 2021 Elsevier Inc.

DOI: doi:10.1016/j.lfs.2020.118973

Abstract

Eosinophils are bi-lobed, multi-functional innate immune cells with diverse cell surface receptors that regulate local immune and inflammatory responses. Several inflammatory and infectious diseases are triggered with their build up in the blood and tissues. The mobilization of eosinophils into the lungs is regulated by a cascade of processes guided by Th2 cytokine generating T-cells. Recruitment of eosinophils essentially leads to a characteristic immune response followed by airway hyperresponsiveness and remodeling, which are hallmarks of chronic respiratory diseases. By analysing the dynamic interactions of eosinophils with their extracellular environment, which also involve signaling molecules and tissues, various therapies have been invented and developed to target respiratory diseases. Having entered clinical testing, several eosinophil targeting therapeutic agents have shown much promise and have further bridged the gap between theory and practice. Moreover, researchers now have a clearer understanding of the roles and mechanisms of eosinophils. These factors have successfully assisted molecular biologists to block specific pathways in the growth, migration and activation of eosinophils. The primary purpose of this review is to provide an overview of the eosinophil biology with a special emphasis on potential pharmacotherapeutic targets. The review also summarizes promising eosinophil-targeting agents, along with their mechanisms and rationale for use, including those in developmental pipeline, in clinical trials, or approved for other respiratory disorders.

Item Details

Item Type:Refereed Article
Keywords:Eosinophils, Immunity, Lung; Pulmonary, Respiratory diseases, Targeted therapies
Research Division:Biomedical and Clinical Sciences
Research Group:Pharmacology and pharmaceutical sciences
Research Field:Pharmaceutical delivery technologies
Objective Division:Health
Objective Group:Clinical health
Objective Field:Prevention of human diseases and conditions
UTAS Author:Shastri, M (Mr Madhur Shastri)
ID Code:152635
Year Published:2021
Web of Science® Times Cited:7
Deposited By:Pharmacy
Deposited On:2022-08-22
Last Modified:2022-09-13
Downloads:0

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