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SARS-CoV-2 Vaccines: where are we now?


Flanagan, KL and MacIntyre, CR and McIntyre, PB and Nelson, MR, SARS-CoV-2 Vaccines: where are we now?, Journal of Allergy and Clinical Immunology: In Practice, 9, (10) pp. 3535-3543. ISSN 2213-2198 (2021) [Refereed Article]

DOI: doi:10.1016/j.jaip.2021.07.016


The best and safest way to control the coronavirus disease 2019 (COVID-19) pandemic is by using vaccination to generate widespread immunity. The urgent need to develop safe and effective COVID-19 vaccines was met with unprecedented speed and action from the global community. There are now 289 vaccines in the development pipeline. More remarkably, there are 20 publicly available vaccines, and more than 3.3 billion doses of COVID-19 vaccines have been administered across 180 countries. This is just the beginning of our fight against the pandemic. Even at the current vaccination rate, it could take years to vaccinate the world's population; many high-income countries are focusing on their needs, whereas the poorer nations are waiting for vaccines. There is still much that we do not understand about immunity to this new disease, and we will have to contend with the emerging variants. In this commentary, we describe the current status of COVID-19 vaccine development and provide insights into how the development and approvals happened so quickly. We discuss the clinical trial data that led to rapid emergency use authorization and the many challenges of global rollout. We also comment on some of the key unanswered questions and future directions for COVID-19 vaccine development and deployment.

Item Details

Item Type:Refereed Article
Keywords:COVID-19 vaccines, DNA, Efficacy, Platforms, RNA, Regulatory pathway, Vaccination program, Viral vector
Research Division:Biomedical and Clinical Sciences
Research Group:Immunology
Research Field:Cellular immunology
Objective Division:Health
Objective Group:Public health (excl. specific population health)
Objective Field:Health protection and disaster response
UTAS Author:Flanagan, KL (Dr Katie Flanagan)
ID Code:152587
Year Published:2021
Web of Science® Times Cited:16
Deposited By:School of Medicine
Deposited On:2022-08-22
Last Modified:2022-10-20

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