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Modulating the microbiome and immune responses using whole plant fibre in synbiotic combination with fibre-digesting probiotic attenuates chronic colonic inflammation in spontaneous colitic mice model of IBD

Citation

Shinde, TS and Vemuri, R and Shastri, Sonia and Perera, AP and Gondalia, SV and Beale, DJ and Karpe, AV and Eri, R and Stanley, R, Modulating the microbiome and immune responses using whole plant fibre in synbiotic combination with fibre-digesting probiotic attenuates chronic colonic inflammation in spontaneous colitic mice model of IBD, Nutrients, 12, (8) pp. 1-26. ISSN 2072-6643 (2020) [Refereed Article]

DOI: doi:10.3390/nu12082380

Abstract

A probiotic and prebiotic food ingredient combination was tested for synergistic functioning in modulation of the colonic microbiome and remediation of the gastrointestinal immune and inflammatory responses in a spontaneous colitic mouse model.Bacillus coagulansMTCC5856 spores with capability to metabolise complex plant polysaccharides were supplemented with complex whole-plant prebiotic sugarcane fibre (PSCF). The combined and individual efficacies were tested for their influence on the outcomes of chronic inflammation inMuc2mutant colitic Winnie mice. The mice were fed normal chow diet supplemented with either ingredient or a combination for 21 days. Synbiotic combined supplementation ameliorated clinical symptoms and histological colonic damage scores more effectively than eitherB. coagulansor PSCF alone. PSCF andB. coagulansalone also induced considerable immunomodulatory effects. Synbiotic supplementation however was the most efficacious in modulating the overall immune profile compared to the unsupplemented Winnie-control. The augmented synbiotic effect could potentially be due to a combination of increased levels of fermentation products, direct immune-modulating abilities of the components, their capability to reduce colonic epithelial damage and/or modulation of the microbiota. The beneficial effects of the supplementation with a complex plant fibre and a fibre-degrading probiotic parallel the effects seen in human microbiota with high plant fibre diets.

Item Details

Item Type:Refereed Article
Keywords:synbiotic, prebiotic; probiotic, Inflammatory Bowel Diseases (IBD), Bacillus spores, whole plant sugarcane fibre, Short chain fatty acids (SCFAs), dysbiosis, gut microbiota
Research Division:Biomedical and Clinical Sciences
Research Group:Nutrition and dietetics
Research Field:Food properties (incl. characteristics and health benefits)
Objective Division:Health
Objective Group:Clinical health
Objective Field:Prevention of human diseases and conditions
UTAS Author:Shinde, TS (Ms Tanvi Shinde)
UTAS Author:Vemuri, R (Mr Ravichandra Vemuri)
UTAS Author:Shastri, Sonia (Mrs Sonia Shastri)
UTAS Author:Perera, AP (Mrs Agampodi Perera)
UTAS Author:Eri, R (Associate Professor Raj Eri)
UTAS Author:Stanley, R (Professor Roger Stanley)
ID Code:152578
Year Published:2020
Web of Science® Times Cited:8
Deposited By:Medicine
Deposited On:2022-08-22
Last Modified:2022-09-05
Downloads:0

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