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Potential role of flavonoids against sars-cov-2 induced diarrhea


Paul, AK and Jahan, R and Bondhon, TA and Jannat, K and Hasan, A and Rahmatullah, M and Nissapatorn, V and Pereira, ML and Wiart, C, Potential role of flavonoids against sars-cov-2 induced diarrhea, Tropical Biomedicine, 38, (3) pp. 360-365. ISSN 0127-5720 (2021) [Refereed Article]

Copyright Statement

2021. The Authors. Published by Malaysian Society of Parasitology and Tropical Medicine.

DOI: doi:10.47665/TB.38.3.079


COVID-19, caused by the SARS-CoV-2 virus, can lead to massive inflammation in the gastrointestinal tract causing severe clinical symptoms. SARS-CoV-2 infects lungs after binding its spike proteins with alveolar angiotensin-converting enzyme 2 (ACE2), and it also triggers inflammation in the gastrointestinal tract. SARS-CoV-2 invades the gastrointestinal tract by interacting with Toll-like receptor-4 (TLR4) that induces the expression of ACE2. The influx of ACE2 facilitates cellular binding of more SARS-CoV-2 and causes massive gastrointestinal inflammation leading to diarrhea. Diarrhea prior to COVID-19 infection or COVID-19-induced diarrhea reportedly ends up in a poor prognosis for the patient. Flavonoids are part of traditional remedies for gastrointestinal disorders. Preclinical studies show that flavonoids can prevent infectious diarrhea. Recent studies show flavonoids can inhibit the multiplication of SARS-CoV-2. In combination with vitamin D, flavonoids possibly activate nuclear factor erythroid-derived-2-related factor 2 that downregulates ACE2 expression in cells. We suggest that flavonoids have the potential to prevent SARS-CoV-2 induced diarrhea.

Item Details

Item Type:Refereed Article
Research Division:Health Sciences
Research Group:Traditional, complementary and integrative medicine
Research Field:Traditional, complementary and integrative medicine not elsewhere classified
Objective Division:Health
Objective Group:Clinical health
Objective Field:Prevention of human diseases and conditions
UTAS Author:Paul, AK (Dr Alok Paul)
ID Code:152483
Year Published:2021
Web of Science® Times Cited:5
Deposited By:Office of the School of Health Sciences
Deposited On:2022-08-19
Last Modified:2022-11-23

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