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Omega-3 Index, fish consumption, use of fish oil supplements and first clinical diagnosis of central nervous system demyelination


Daly, A and Martin, C and Sherriff, J and Mori, TA and Pereira, G and Lucas, RM and Ponsonby, A-L and Taylor, B and van der Mei, I and Black, LJ, Ausimmune Investigator Group, Omega-3 Index, fish consumption, use of fish oil supplements and first clinical diagnosis of central nervous system demyelination, Multiple Sclerosis and Related Disorders, 55 pp. 1-4. ISSN 2211-0348 (2021) [Refereed Article]

Copyright Statement

2021 Elsevier B.V.

DOI: doi:10.1016/j.msard.2021.103210


Higher intakes of omega-3 polyunsaturated fatty acids (n3PUFAs) have been associated with lower MS risk. We aimed to test associations between the Omega-3 Index, blood levels of n3PUFAs, fish oil supplement use, and fish consumption with a first clinical diagnosis of CNS demyelination (FCD). Cases (n, = 250) had a higher Omega-3 Index compared with a matched group of controls (n = 471) (average treatment effect (ATE)=0.31, p = 0.047, based on augmented inverse probability weighting). A higher percentage of cases than controls used fish oil supplements (cases=17% vs. controls=10%). We found that Omega-3 Index increased as time between FCD and study interview increased (e.g., at or below median (112 days), based on ATE, mean=5.30, 95% CI 5.08, 5.53; above median, mean=5.90, 95% CI 5.51, 6.30). Fish oil supplement use increased in a similar manner (at or below median (112 days), based on ATE, proportion=0.12, 95% CI 0.06, 0.18; above the median, proportion=0.21, 95% CI 0.14, 0.28). Our results suggest a behaviour change post FCD with increased use of fish oil supplements.

Item Details

Item Type:Refereed Article
Keywords:Ausimmune study; fish oil supplements; multiple sclerosis; omega-3 index; polyunsaturated fatty acids
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Neurology and neuromuscular diseases
Objective Division:Health
Objective Group:Clinical health
Objective Field:Prevention of human diseases and conditions
UTAS Author:Taylor, B (Professor Bruce Taylor)
UTAS Author:van der Mei, I (Professor Ingrid van der Mei)
ID Code:152451
Year Published:2021
Web of Science® Times Cited:2
Deposited By:Menzies Institute for Medical Research
Deposited On:2022-08-19
Last Modified:2022-09-07

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