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Sugar-Sweetened Beverage Consumption May Modify Associations Between Genetic Variants in the CHREBP (Carbohydrate Responsive Element Binding Protein) Locus and HDL-C (High-Density Lipoprotein Cholesterol) and Triglyceride Concentrations

Citation

Haslam, DE and Peloso, GM and Guirette, M and Imamura, F and Bartz, TM and Pitsillides, AN and Wang, CA and Li-Gao, R and Westra, JM and PitkA nen, N and Young, KL and Graff, M and Wood, AC and Braun, KVE and Luan, J and KA hA nen, M and Kiefte-De Jong, JC and Ghanbari, M and Tintle, N and Lemaitre, RN and Mook-Kanamori, DO and North, K and Helminen, M and Mossavar-Rahmani, Y and Snetselaar, L and Martin, LW and Viikari, JS and Oddy, WH and Pennell, CE and Rosendall, FR and Ikram, MA and Uitterlinden, AG and Psaty, BM and Mozaffarian, D and Rotter, JI and Taylor, KD and LehtimA ki, T and Raitakari, OT and Livingston, KA and Voortman, T and Forouhi, NG and Wareham, NJ and De Mutsert, R and Rich, SS and Manson, JAE and Mora, S and Ridker, PM and Merino, J and Meigs, JB and Dashti, HS and Chasman, DI and Lichtenstein, DI and Smith, CE and Dupuis, J and Herman, MA and McKeown, NM, Sugar-Sweetened Beverage Consumption May Modify Associations Between Genetic Variants in the CHREBP (Carbohydrate Responsive Element Binding Protein) Locus and HDL-C (High-Density Lipoprotein Cholesterol) and Triglyceride Concentrations, Circulation: Genomic and Precision Medicine, 14, (4) pp. 506-516. ISSN 2574-8300 (2021) [Refereed Article]


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DOI: doi:10.1161/CIRCGEN.120.003288

Abstract

Background:ChREBP (carbohydrate responsive element binding protein) is a transcription factor that responds to sugar consumption. Sugar-sweetened beverage (SSB) consumption and genetic variants in the CHREBP locus have separately been linked to HDL-C (high-density lipoprotein cholesterol) and triglyceride concentrations. We hypothesized that SSB consumption would modify the association between genetic variants in the CHREBP locus and dyslipidemia.

Methods:Data from 11 cohorts from the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium (N=63 599) and the UK Biobank (N=59 220) were used to quantify associations of SSB consumption, genetic variants, and their interaction on HDL-C and triglyceride concentrations using linear regression models. A total of 1606 single nucleotide polymorphisms within or near CHREBP were considered. SSB consumption was estimated from validated questionnaires, and participants were grouped by their estimated intake.

Results: In a meta-analysis, rs71556729 was significantly associated with higher HDL-C concentrations only among the highest SSB consumers (β, 2.12 [95% CI, 1.16-3.07] mg/dL per allele; P<0.0001), but not significantly among the lowest SSB consumers (P=0.81; PDiff <0.0001). Similar results were observed for 2 additional variants (rs35709627 and rs71556736). For triglyceride, rs55673514 was positively associated with triglyceride concentrations only among the highest SSB consumers (β, 0.06 [95% CI, 0.02-0.09] ln-mg/dL per allele, P=0.001) but not the lowest SSB consumers (P=0.84; PDiff=0.0005).

Conclusions: Our results identified genetic variants in the CHREBP locus that may protect against SSB-associated reductions in HDL-C and other variants that may exacerbate SSB-associated increases in triglyceride concentrations. Registration: URL: https://www.clinicaltrials.gov; Unique identifier: NCT00005133, NCT00005121, NCT00005487, and NCT00000479.

Item Details

Item Type:Refereed Article
Keywords:carbohydrates, dyslipidemia, epidemiology, genetics, nutrition, sugars, triglyceride
Research Division:Biomedical and Clinical Sciences
Research Group:Nutrition and dietetics
Research Field:Food properties (incl. characteristics and health benefits)
Objective Division:Health
Objective Group:Evaluation of health and support services
Objective Field:Determinants of health
UTAS Author:Oddy, WH (Professor Wendy Oddy)
ID Code:152442
Year Published:2021
Web of Science® Times Cited:3
Deposited By:Medicine
Deposited On:2022-08-19
Last Modified:2022-08-25
Downloads:0

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